Current Colorectal Cancer Reports

, Volume 5, Issue 2, pp 69–74

The role of inflammation in the pathogenesis of colorectal cancer


DOI: 10.1007/s11888-009-0011-z

Cite this article as:
McConnell, B.B. & Yang, V.W. Curr colorectal cancer rep (2009) 5: 69. doi:10.1007/s11888-009-0011-z


Chronic inflammatory disorders are often associated with an increased risk of developing cancer. A classic example of the connection between inflammation and cancer is the increased risk of colorectal cancer in patients with inflammatory bowel disease (IBD). In this review, we discuss aspects of IBD that promote colorectal cancer and highlight key molecular mediators that contribute to cancer risk. Additionally, we report on progress in identifying molecular targets that may prove efficacious in blocking the progression of IBD-related inflammation to cancer.

Copyright information

© Current Medicine Group, LLC 2009

Authors and Affiliations

  1. 1.Division of Digestive Diseases, Department of MedicineEmory University School of MedicineAtlantaUSA