Can Catheter-Based Renal Denervation Be Used Safely and Effectively to Substantially Reduce Blood Pressure in Treatment-Resistant Hypertensive Patients?
- Suzanne Oparil
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Trial: Esler MD, Krum H, Sobotka PA, et al.: Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet 2010, 376:1903–1909.
Rating: Of significant importance.
Introduction: Successful treatment of elevated blood pressure (BP) has proven elusive despite availability of various drugs, combination pharmaceutical products, and resources to assist patients’ adherence and lifestyle changes. The failure of present strategies suggests underlying pathophysiology that is refractory to available interventions. Renal sympathetic nerves contribute to development and perpetuation of hypertension, and sympathetic outflow to the kidneys is activated in patients with essential hypertension. Efferent sympathetic outflow stimulates renin release, increases tubular sodium reabsorption, and reduces renal blood flow. Afferent signals from the kidney modulate central sympathetic outflow and thereby directly contribute to
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- Can Catheter-Based Renal Denervation Be Used Safely and Effectively to Substantially Reduce Blood Pressure in Treatment-Resistant Hypertensive Patients?
Current Cardiology Reports
Volume 13, Issue 6 , pp 478-480
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- Online ISSN
- Current Science Inc.
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- Renal denervation
- Resistant hypertension
- Blood pressure
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- Suzanne Oparil (1)
- Author Affiliations
- 1. Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, School of Medicine, University of Alabama at Birmingham, 703 19th Street South, Birmingham, AL, 35294, USA