Current Cardiology Reports

, 13:364

Genetics of Sudden Cardiac Death

  • Alon Barsheshet
  • Andrew Brenyo
  • Arthur J. Moss
  • Ilan Goldenberg
Article

DOI: 10.1007/s11886-011-0209-y

Cite this article as:
Barsheshet, A., Brenyo, A., Moss, A.J. et al. Curr Cardiol Rep (2011) 13: 364. doi:10.1007/s11886-011-0209-y

Abstract

Advances in genetic testing technology have led to a proliferation of new genetic tests and accelerated developments in the field of cardiovascular genetic medicine. These advances enhance presymptomatic diagnosis and can establish a definitive molecular diagnosis for symptomatic patients at risk for sudden cardiac death. Most importantly, genotype-phenotype correlations can add important information for predicting outcome and selecting treatment for patients with inherited arrhythmic disorders. This paper reviews the current data regarding genotype-phenotype correlations and the role of clinical genetic testing in diagnosis, prognosis, and management of inheritable disorders leading to sudden cardiac death.

Keywords

Sudden cardiac deathSCDGeneticsArrhythmiaGenetic testingGenesRisk assessmentDiagnosisPrognosisAborted cardiac arrestHypertrophic cardiomyopathyDilated cardiomyopathyARVC/DLong QT syndromeLQTSShort QT syndromeBrugada syndromeCatecholaminergic polymorphic ventricular tachycardiaCPVT

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Alon Barsheshet
    • 1
  • Andrew Brenyo
    • 1
  • Arthur J. Moss
    • 1
  • Ilan Goldenberg
    • 1
  1. 1.Heart Research Follow-up ProgramUniversity of Rochester Medical CenterRochesterUSA