Current Cardiology Reports

, Volume 13, Issue 1, pp 86–92

Premise, Promise, and Potential Limitations of Invasive Devices to Treat Hypertension


DOI: 10.1007/s11886-010-0156-z

Cite this article as:
Martin, E.A. & Victor, R.G. Curr Cardiol Rep (2011) 13: 86. doi:10.1007/s11886-010-0156-z


Invasive device-based therapies for drug-resistant hypertension are undergoing active clinical investigation. The two approaches are 1) permanent implantation of a carotid baroreceptor pacemaker and 2) radiofrequency catheter ablation of the renal nerves. Both are designed to reduce the sympathetic nervous system component of drug-resistant hypertension. Several excellent comprehensive articles have reviewed each of these devices separately. In contrast, this brief article aims to provide a conceptual framework for evaluating the premise, promise, and potential limitations of both invasive antihypertensive therapies.


HypertensionCarotid baroreceptor pacemakerRadiofrequency catheter ablationAntihypertensive therapiesSympathetic nervous systemParasympathetic nervous systemSympathetic overactivityNorepinephrineRenal vasoconstrictionReninSodiumVascular resistanceBlood pressureBlood flowHeart rateEfferent renal nervesAfferent renal nervesKidney diseaseRenal diseaseHeart failureLeft ventricular dysfunctionInnervationDenervationElectrical stimulation

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Hypertension CenterCedars-Sinai Heart InstituteLos AngelesUSA