Current Cardiology Reports

, Volume 12, Issue 5, pp 440-445

Contrast-Induced Acute Kidney Injury: The At-Risk Patient and Protective Measures

  • Jeremiah R. BrownAffiliated withThe Dartmouth Institute for Health Policy and Clinical Practice, Section of Cardiology, Dartmouth Medical School
  • , Craig A. ThompsonAffiliated withInvasive Cardiology and Vascular Medicine, Yale University School of Medicine Email author 

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Contrast-induced acute kidney injury (CI-AKI) is a major complication following radiocontrast procedures. In this review, we characterize the recent literature on CI-AKI, risk factors, prevention, biomarkers, and new technologies. The premise of CI-AKI prophylaxis should focus on implementing mandatory standing orders before and after cardiac catheterization for hydration with normal saline or sodium bicarbonate and use of high-dose (1200-mg) N-acetylcysteine. Contrast agents may play a role in preventing CI-AKI. Implement catheter-laboratory technology and awareness to limit the amount of contrast dye used for any patient.


Radiocontrast Nephropathy Kidney injury Cardiac catheterization Prevention Risk factors