Current Cardiology Reports

, Volume 12, Issue 3, pp 216–222

Myocardial Ischemia in Patients with Diastolic Dysfunction and Heart Failure

  • Thomas E. Vanhecke
  • Robert Kim
  • Shaheena Z. Raheem
  • Peter A. McCullough
Article

DOI: 10.1007/s11886-010-0101-1

Cite this article as:
Vanhecke, T.E., Kim, R., Raheem, S.Z. et al. Curr Cardiol Rep (2010) 12: 216. doi:10.1007/s11886-010-0101-1

Abstract

Coronary artery disease is present in 40–55% of patients with diastolic heart failure, and myocardial ischemia is both a cause and a precipitant of diastolic heart failure. Failure to recognize and treat acute and chronic ischemia in patients with this disorder results in rapid disease progression and poor outcomes. In diastolic heart failure patients without obstructive coronary artery disease, ischemia can be induced by other diseases that diminish perfusion gradient, cause myocardium to outgrow blood supply, or decrease diastolic filling time. In this article, we review the role of ischemia and development of fibrosis in the epidemiology, pathophysiology, and evaluation of patients with diastolic dysfunction and diastolic heart failure.

Keywords

Diastolic heart failure Myocardial ischemia Diastolic dysfunction Diastolic heart failure 

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Thomas E. Vanhecke
    • 1
  • Robert Kim
    • 1
  • Shaheena Z. Raheem
    • 1
  • Peter A. McCullough
    • 1
  1. 1.Department of Cardiovascular Medicine, Division of Nutrition and Preventive MedicineWilliam Beaumont HospitalRoyal OakUSA

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