Current Cardiology Reports

, Volume 12, Issue 2, pp 140–146

Screening Asymptomatic Patients with Type 2 Diabetes Mellitus for Coronary Artery Disease: Does It Improve Patient Outcome?


DOI: 10.1007/s11886-010-0091-z

Cite this article as:
Shirani, J. & Dilsizian, V. Curr Cardiol Rep (2010) 12: 140. doi:10.1007/s11886-010-0091-z


The increasing global burden, the reported high prevalence of rapidly progressive coronary artery disease (CAD), and the atypical nature of CAD presentation in type 2 diabetes mellitus have encouraged development of strategies for detecting occult CAD in this population. Several recent prospective studies have addressed the value of screening for CAD in asymptomatic diabetic patients. The overall message of these studies is that despite detection of silent ischemia in a notable proportion of these patients, the dynamic nature of myocardial ischemia, the prohibitive cost of screening all asymptomatic patients, and the proven efficacy of primary preventive strategies would mandate implementation of better clinical risk stratification strategies for identifying at-risk individuals. Questions still remain as to what best strategy would allow proper patient selection through logical stepwise approaches to screening and whether that would alter patients’ outcome when added to rigorously implemented primary preventive measures.


Coronary artery diseaseDiabetes mellitusDetection of ischemia in asymptomatic diabetes (DIAD)Myocardial perfusion imagingScreeningPrognosis

Clinical Trial Acronyms


Action to Control Cardiovascular Risk in Diabetes


Action in Diabetes and Vascular Disease: Preterax and Diamicron-MR Controlled Evaluation


Bypass Angioplasty Revascularization Investigation in Type 2 Diabetics Trial


Diabetes Control and Complications Trial


Detection of Ischemia in Asymptomatic Diabetics


Multicenter Trial of Elective Revascularization in Patients With Diabetes Mellitus and Mild Anginal Complaints


Milan Study on Atherosclerosis and Diabetes


National Health and Nutrition Examination Survey


United Kingdom Prospective Diabetes Study


Veterans Affairs Diabetes Trial

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of CardiologyGeisinger Medical CenterDanvilleUSA
  2. 2.Department of Diagnostic Radiology and Nuclear MedicineThe University of Maryland Hospital and School of MedicineBaltimoreUSA