Genetic determinants of drug response in heart failure
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- Lowes, B.D. & Buttrick, P.M. Curr Cardiol Rep (2008) 10: 176. doi:10.1007/s11886-008-0031-3
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Heart failure management is complex and costly. Genetic variations that alter drug absorption, metabolism, and receptor-ligand interactions have the potential to modify drug response and safety. Evidence shows that genetic factors interact with numerous heart failure medications, including vasodilators, β blockers, and angiotensin-converting enzyme inhibitors. Technologic advances will soon allow population-based genome-wide genetic testing at a reasonable cost. Understanding the genetic factors that influence drug response in heart failure will allow physicians to personalize therapies and optimize response while minimizing serious adverse events.