Current Cardiology Reports

, Volume 10, Issue 1, pp 37–42

Neuroprotection in cerebral ischemia: Emphasis on the SAINT trial

  • Marcus R. Chacon
  • Matt B. Jensen
  • Justin A. Sattin
  • Justin A. Zivin
Article

DOI: 10.1007/s11886-008-0008-2

Cite this article as:
Chacon, M.R., Jensen, M.B., Sattin, J.A. et al. Curr Cardiol Rep (2008) 10: 37. doi:10.1007/s11886-008-0008-2

Abstract

Acute ischemic stroke (AIS) is a significant cause of death and disability in the United States. It has been 10 years since tissue plasminogen activator became the first medication approved by the US Food and Drug Administration for treatment for AIS. However, this treatment simply reopens arteries. The identification of deleterious cellular reactions that occur secondary to cerebral ischemia has led investigators to search for neuroprotection strategies to complement reperfusion. More than 100 human trials, including a handful of phase III trials, had failed to produce an efficacious neuroprotective agent. In 2006, the first positive trial of neuroprotection was published: the SAINT I (Stroke-Acute Ischemic NXY Treatment) study. In February 2008, the SAINT II study was published, indicating that NXY-059 was not effective for AIS treatment.

Copyright information

© Current Medicine Group LLC 2008

Authors and Affiliations

  • Marcus R. Chacon
  • Matt B. Jensen
  • Justin A. Sattin
    • 1
  • Justin A. Zivin
  1. 1.Department of NeurosciencesUniversity of California San DiegoLa JollaUSA