Herbal medicine: Beneficial effects, side effects, and promising new research in the treatment of arrhythmias
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Herbal medications and dietary supplements are unregulated in the United States. The use of these medications has dramatically increased over the past decade. Many of these drugs are biologically active, yet physicians are often unaware their patients are using a traditional remedy. Physicians are frequently unfamiliar with the medications being used and the intended effect, as well as the side-effect profiles that accompany them. Recently, some of the herbal mediations that are commonly used in the general population have been shown to be beneficial for the treatment of arrhythmias. Unfortunately, many more have been shown to be detrimental. In this article, the background behind herbal medication and the degree to which herbal medications are being used is reviewed. Herbal medications known to have beneficial effects in the treatment of arrhythmias, as well as those that have known detrimental effects with regard to cardiac arrhythmias, are highlighted. Finally, research that has been done in this field, focusing on those compounds that have been shown to be biologically active in the treatment of cardiac arrhythmias, are reviewed.
- Eisenberg DM, Kessler RC, Foster C, et al.: Unconventional medicine in the United States. Prevalence, costs, and patterns of use. N Engl J Med 1993, 328:246–252. CrossRef
- Sardesai VM: Herbal medicines: poisons or potions? J Lab Clin Med 2002, 139:343–348. Analysis of population-based use of herbal medications and alternative medicine. CrossRef
- Astin JA: Why patients use alternative medicine: results of a national study [comment]. JAMA 1998, 279:1548–1553. Demographics of alternative medicine use in the United States. Analysis of patient perspectives on use of alternative medicine. CrossRef
- Olshansky B, Shivkumar K: Patient-heal thyself? Electrophysiology meets alternative medicine [editorial]. PACE 2001, 24:403–405.
- Abarquez RF: The old but reliable digitalis: persistent concerns and expanded indications. Int J Clin Prac 2001, 55:108–114.
- Davies MK, Hollman A: Atropa belladonna. Heart 2002, 88:215. CrossRef
- Olshansky B: Alternative medicine: boom or bust? Cardiac Electrohpysiol Rev 2002, 6:170–173. CrossRef
- Olshansky B: Arrhythmias. In Integrative Medicine: Complementary Therapy in Medical Practice. New York: Elsevier; 2002:195–206.
- Chen ZY: Use of Xin Bao in the treatment of 87 patients with sick sinus syndrome [Chinese]. Chin J Mod Dev Tradition Med (Chung Hsi i Chieh Ho Tsa Chih) 1990, 10:529–531.
- Soter D, Chan M, Lee S, et al.: The antiarrhythmic effects of Sophora Flavescens Ait. in rats and mice. Am J Chin Med 1986, 14:119–123. CrossRef
- Martin N, Bardisa L, Pantoja C, et al.: Anti-arrhythmic profile of a garlic dialysate assayed in dogs and isolated atrial preparations. J Ethnopharmacol 1994, 43:1–8. CrossRef
- Lu L, Habuchi Y, Tanaka H, et al.: Electrophysiological effects of Changrolin, an anti-arrhythmic agent derived from Dichroa febrifuga, on Guinea-pig and rabbit heart cells. Clin Exp Pharmacol Physiol 1995, 22:337–341.
- Slifman NR, Obermeyer WR, Aloi BK, et al.: Contamination of botanical dietary supplements by Digitalis lanata. N Engl J Med 1998, 339:806–811. CrossRef
- Hutchins GM: Ma Huang toxicity [letter]. Mayo Clin Proc 2002, 77:733.
- Bell DG, Jacobs I, Zamecnik J: Effecgts of caffeine, ephedrine and their combination on time to exhaustion during highintensity exercise. Eur J Appl Physiol 1998, 77:427–433. CrossRef
- Samenuk D, Link MS, Homoud MK, et al.: Adverse cardiovascular events temporally assosciated with Ma Huang, an herbal source of ephedrine. Mayo Clin Proc 2002, 77:12–16. CrossRef
- Haller CA, Benowitz NL: Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med 2000, 343:1833–1838. CrossRef
- Theoharides T: Sudden death of a healthy college student related to ephedrine toxicity from a Ma Huang-containing drink [letter]. J Clin Psychopharmacol 1997, 17:437–439. CrossRef
- American Cancer Society. http:/www.acs.org. Accessed April 25, 2003.
- Saliba W, Erdogan O, Niebauer M: Polymorphic ventricular tachycardia in a woman taking cesium chloride. Pacing Clin Electrophysiol 2001, 24:515–517. CrossRef
- Pinter A, Dorian P, Newman D: Cesium-induced Torsades de pointes. N Engl J Med 2002, 346:383–384. CrossRef
- Tsai SK, Huang SS, Hong CY: Myocardial protective effects of Honokiol: an active component in Magnolia officinalis. Planta Medica 1996, 62:503–506. CrossRef
- Garjani A, Nazemiyeh H, Maleki N, et al.: Effects of extracts from flowering tops of Crataegus meyeri A. Pojark. on ischaemic arrhythmias in anaesthetized rats. Phytother Res 2000, 14:428–431. CrossRef
- Xiaofang W, Jingchun Z, Dazhuo S, et al.: Clinical observation on 84 cases of ventricular premature beat with deficiency syndrome treated by Qi Lu Tang. J Tradition Chin Med 1998, 18:83–86.
- Pu H, Huang X, Zhao J, et al.: Bergenin is the principle antiarrhythmic of Fluggea virosa. Planta Medica 2002, 68:370–372. CrossRef
- Zhu BQ: Clinical efficacy of aconitic injection in asthenia patients suffering from sick sinus syndrome and its mechanism. Chin J Mod Dev Tradition Med (Chung Hsi i Chieh Ho Tsa Chih) 1993, 5:219–22.
- Wangming L, et al.: Clinical efficacy of huxindan in patients with sick sinus syndrome. Chin J Integ Med 1984, 4:590.
- Wang D, Mao H, Lei M, et al.: Clinical study of rotundium in treating atrial fibrillation. Chin J Integ Med 1993, 13:455.
- Guo Z: Electrophysiological effects of neferine against ischemic ventricular tachyarrhythmias. Chin J Cardiol 1992, 20:119–122.
- Liu JX, Shang XH, Wang G: Effect of tongxinluo capsule on experimental myocardial ischemia, arrhythmia and hyperlipidemia. Chung-Kuo Chung Hsi i Chieh Ho Tsa Chih 1997, 17:425–428.
- Wang YX, Zheng YM, Tan YH, et al.: Anti-atrial fibrillation effects of cyclovirobuxine-D and its electrophysiological mechanism studied on guinea pig atria. Yao Hsueh Hsueh Pao — Acta Pharmaceutica Sinica 1996, 31:481–486.
- Zheng R, Fang S, Li Z, et al.: Prevention of arrhythmia in rats by puhuang. Chin J Med 1993, 18:108.
- Zheng Y, Gong K, Yao X, et al.: Clinical observation on treatment of bradyarrhythmia with Chinese herbal medicine. J Tradition Chin Med 1993, 13:163–168.
- MotherNature.com. http:/www.mothernature.com. Accessed April 25, 2003. Searchable database of herbal medications and dietary supplements with positive and negative effects.
- Herbal medicine: Beneficial effects, side effects, and promising new research in the treatment of arrhythmias
Current Cardiology Reports
Volume 5, Issue 5 , pp 395-401
- Cover Date
- Print ISSN
- Online ISSN
- Current Medicine Group
- Additional Links