Current Cardiology Reports

, Volume 5, Issue 4, pp 289-295

First online:

Revised guidelines for the management of non-ST-segment elevation acute coronary syndromes

  • Debabrata MukherjeeAffiliated withDivision of Cardiology, University of Michigan Health System
  • , Kim A. EagleAffiliated withDivision of Cardiology, University of Michigan Health System

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


Unstable angina (UA) and non-ST-segment elevation myocardial infarction (NSTEMI) refer to a spectrum of acute severe cardiac disorders characterized by myocardial oxygen demand and supply mismatch, caused by atherosclerotic coronary artery disease. Patients presenting with acute coronary syndromes represent a major medical problem, accounting for 2.5 million hospitalizations and 500,000 deaths annually in the United States alone. Of these, 1.5 million have a final diagnosis of UA, and myocardial infarction (ST-segment and non-ST-segment elevation) accounts for the remaining 1 million. The management of UA/NSTEMI presents a challenge to the cardiologist because treatment strategies continue to evolve. A number of trials have now assessed the safety and efficacy of early revascularization strategies in the treatment of patients with UA/NSTEMI, whereas others have focused on pharmacologic adjunctive therapy. An optimal single strategy encompassing most patients’ needs is not clear. This review focuses on the revised American College of Cardiology/ American Heart Association guidelines for the management of patients presenting with UA/NSTEMI.