Current Cardiology Reports

, Volume 4, Issue 6, pp 501–507

The effects of errors in lipid measurement and assessment

  • Gerald R. Cooper
  • Gary L. Myers
  • Mary M. Kimberly
  • Parvin P. Waymack
Article

DOI: 10.1007/s11886-002-0114-5

Cite this article as:
Cooper, G.R., Myers, G.L., Kimberly, M.M. et al. Curr Cardiol Rep (2002) 4: 501. doi:10.1007/s11886-002-0114-5

Abstract

Accurate cholesterol and lipoprotein measurements have provided dependable and powerful basic risk factors for cardiovascular disease. A battery of total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, and triglycerides (TG) is recommended in the initial evaluation for classification of patients (based on lipids) into highly desirable, desirable, borderline, high, and very high lipid risk factor for cardiovascular disease. Treatment is based largely on the LDL cholesterol measurement result of the patient. The risk factor score of a patient greatly increases when other risk factors for cardiovascular disease exist, along with increased lipid risk factors. Attainment of the needed acceptable accurate lipid and lipoprotein measurements depends upon prevention or control of multiple sources of errors or variation that can exist in preanalytic, analytic, and postanalytic stages of determination of the reported result. Highly important is to control nonfasting, posture, diet, and alcohol intake in the preanalytic part, elimination of matrix effects and use of accurate calibrators in the analytic part, and check for transcription errors in preparation of reports in the postanalytic part of the measurement of lipids.

Copyright information

© Current Science Inc 2002

Authors and Affiliations

  • Gerald R. Cooper
    • 1
  • Gary L. Myers
  • Mary M. Kimberly
  • Parvin P. Waymack
  1. 1.Division of Laboratory Sciences, National Center for Environmental HealthCenters for Disease Control and PreventionAtlantaUSA