Current Cardiology Reports

, Volume 3, Issue 5, pp 355–361

Platelet glycoprotein IIb/IIIa inhibitors for acute coronary syndromes: Initiate treatment early or wait for the catheterization laboratory?

  • David J. Harnick
  • David A. Vorchheimer
Article

DOI: 10.1007/s11886-001-0051-8

Cite this article as:
Harnick, D.J. & Vorchheimer, D.A. Curr Cardiol Rep (2001) 3: 355. doi:10.1007/s11886-001-0051-8

Abstract

Treatment of patients with acute coronary syndromes (ACS) incorporates several approaches to reverse or mitigate the thrombus, which invariably is at the center of the pathophysiologic process of ACS. Pharmacologic and mechanical strategies are designed to prevent death, reduce myocardial necrosis, and stabilize the plaque to prevent later sequelae. Conventional antithrombotic therapy includes antiplatelet and anticoagulant drugs. Medications that inhibit the platelet glycoprotein IIb/IIIa receptor have been shown to be especially efficacious in the treatment of ACS. Recent clinical trials have validated a strategy of aggressive revascularization, particularly catheter-based percutaneous procedures. This review summarizes new trial results and provides a working algorithm for care of the patient with ACS.

Copyright information

© Current Science Inc 2001

Authors and Affiliations

  • David J. Harnick
    • 1
  • David A. Vorchheimer
    • 1
  1. 1.The Zena and Michael A. Weiner Cardiovascular InstituteMount Sinai Medical CenterNew YorkUSA