Novel Therapies for Treating Familial Hypercholesterolemia

Nonstatin Drugs (WB Borden, Section Editor)

DOI: 10.1007/s11883-013-0382-0

Cite this article as:
Bandeali, S.J., Daye, J. & Virani, S.S. Curr Atheroscler Rep (2014) 16: 382. doi:10.1007/s11883-013-0382-0
Part of the following topical collections:
  1. Topical Collection on Nonstatin Drugs

Abstract

Familial hypercholesterolemia is an inherited disorder associated with early accelerated atherosclerosis with morbidity and mortality resulting from premature cardiovascular disease. Affected individuals have extreme elevations in low-density lipoprotein cholesterol levels. Patients usually do not achieve target reductions in cholesterol levels with conventional antihyperlipidemic pharmacotherapy. This unmet need has resulted in the recent development and approval of novel therapies targeting different cholesterol pathways. This article briefly summarizes familial hypercholesterolemia and then discusses the newer pharmacotherapies available in the management of familial hypercholesterolemia.

Keywords

Familial hypercholesterolemia Mipomersen Proprotein convertase subtilisin/kexin 9 inhibitors Lomitapide 

Copyright information

© Springer Science+Business Media New York (outside the USA) 2013

Authors and Affiliations

  • Salman J. Bandeali
    • 1
  • Jad Daye
    • 2
  • Salim S. Virani
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
  1. 1.Section of Cardiology, Department of Medicine, Texas Heart InstituteSt. Luke’s Episcopal HospitalHoustonUSA
  2. 2.Department of MedicineBaylor College of MedicineHoustonUSA
  3. 3.Health Policy, Quality, and Informatics ProgramMichael E. DeBakey Veteran Affairs Medical Center Health Services Research and Development Center of ExcellenceHoustonUSA
  4. 4.Section of Cardiovascular Research, Department of MedicineBaylor College of MedicineHoustonUSA
  5. 5.Center for Cardiovascular Disease PreventionHouston Methodist DeBakey Heart and Vascular CenterHoustonUSA
  6. 6.Section of CardiologyMichael E. DeBakey Veterans Affairs Medical CenterHoustonUSA
  7. 7.Health Services Research and Development (152)Michael E. DeBakey Veterans Affairs Medical CenterHoustonUSA

Personalised recommendations