Current Atherosclerosis Reports

, 15:354

Atherosclerosis and Transit of HDL Through the Lymphatic Vasculature

Clinical Trials and Their Interpretations (J Plutzky, Section Editor)

DOI: 10.1007/s11883-013-0354-4

Cite this article as:
Martel, C. & Randolph, G.J. Curr Atheroscler Rep (2013) 15: 354. doi:10.1007/s11883-013-0354-4
Part of the following topical collections:
  1. Topical Collection on Clinical Trials and Their Interpretations


Key components of atherosclerotic plaque known to drive disease progression are macrophages and cholesterol. It has been widely understood, and bolstered by recent evidence, that the efflux of cholesterol from macrophage foam cells quells disease progression or even to promote regression. Following macrophage cholesterol efflux, cholesterol loaded onto HDL must be removed from the plaque environment. Here, we focus on recent evidence that the lymphatic vasculature is critical for the removal of cholesterol, likely as a component of HDL, from tissues including skin and the artery wall. We discuss the possibility that progression of atherosclerosis might in part be linked to sluggish removal of cholesterol from the plaque.


InflammationCardiovascular diseaseReverse cholesterol transportMacrophage

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Pathology and ImmunologyWashington University School of MedicineSt. LouisUSA