Lipid and Metabolic Effects of Gastrointestinal Surgery (F Rubino, Section Editor)

Current Atherosclerosis Reports

, Volume 14, Issue 6, pp 579-587

Gastrointestinal Surgery for Obesity and Diabetes: Weight Loss and Control of Hyperglycemia

  • H. M. HeneghanAffiliated withBariatric and Metabolic Institute, M61, Cleveland Clinic
  • , S. NissenAffiliated withHeart & Vascular Institute, Cleveland Clinic
  • , P. R. SchauerAffiliated withBariatric and Metabolic Institute, M61, Cleveland Clinic Email author 

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Obesity is associated with a variety of weight-related metabolic comorbidities. Bariatric surgery (metabolic/gastrointestinal surgery) not only achieves significant and sustainable weight loss, but also induces extraordinary effects on nearly all obesity-related comorbidities, particularly remission of type 2 diabetes mellitus (T2DM). The mechanisms underlying such effects are slowly being elucidated, and it appears that the metabolic benefits of bariatric surgery are not only attributable to weight loss, but there are also weight independent mechanisms at play. This article outlines the metabolic effects of the most commonly performed bariatric procedures, with a particular emphasis on how they affect glucose metabolism and T2DM.


Obesity Diabetes mellitus Bariatric surgery Metabolic surgery Diabetes remission Weight loss