Current Atherosclerosis Reports

, Volume 14, Issue 5, pp 450–459

Making a Difference: Monocyte Heterogeneity in Cardiovascular Disease

Clinical Trials and Their Interpretations (J Plutzky, Section Editor)

DOI: 10.1007/s11883-012-0274-8

Cite this article as:
Hilgendorf, I. & Swirski, F.K. Curr Atheroscler Rep (2012) 14: 450. doi:10.1007/s11883-012-0274-8

Abstract

Monocytes are frequently described as bone marrow-derived precursors of macrophages. Although many studies support this view, we now appreciate that monocytes neither develop exclusively in the bone marrow nor give rise to all macrophages and dendritic cells. In addition to differentiating to specific leukocyte populations, monocytes, as monocytes, are functionally and ontogenically heterogeneous. In this review we will focus on the development and activity of monocytes and their subsets in mice (Ly-6 Chigh/low) and humans (CD14+/dim/- CD16+/-) in the context of atherosclerosis and its complications.

Keywords

Monocyte subsets Monocyte heterogeneity Ly-6C CD14 CD16 Macrophage Dendritic cells Atherosclerosis Myocardial infarction Cardiovascular disease Extramedullary hematopoeisis Inflammation 

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Center for Systems Biology, Massachusetts General Hospital and Harvard Medical SchoolSimches Research BuildingBostonUSA