MicroRNAs as Biomarkers for Myocardial Infarction
MicroRNAs (miRs) are short non-coding RNA molecules involved in post-transcriptional gene regulation by binding to the 3′ untranslated region of a messenger RNA (mRNA), thereby inhibiting the translation or inducing mRNA destabilization. MiRs are generally considered to act as intracellular mediators essential for normal cardiac function, and their deregulated expression profiles have been associated with cardiovascular diseases. Recent studies have revealed the existence of freely circulating miRs in human peripheral blood, which are present in a stable nature. This has raised the possibility that miRs may be released in the circulation and can serve as novel diagnostic markers for acute or chronic human disorders, including myocardial infarction (MI). This review summarizes the recent findings of miRs that fulfill the criteria of candidate biomarkers for MI.
- MicroRNAs as Biomarkers for Myocardial Infarction
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- Available under Open Access This content is freely available online to anyone, anywhere at any time.
Current Atherosclerosis Reports
Volume 14, Issue 3 , pp 193-200
- Cover Date
- Print ISSN
- Online ISSN
- Current Science Inc.
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- Circulating microRNAs
- Myocardial infarction
- Cardiovascular diagnostics
- Industry Sectors
- Author Affiliations
- 1. Department of Cardiology, Cardiovascular Research Institute, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
- 2. Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Sciences, Utrecht, The Netherlands
- 3. Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands