Current Atherosclerosis Reports

, Volume 13, Issue 6, pp 453–460

Effects of Diet on High-Density Lipoprotein Cholesterol

Nutrition (William S. Harris, Section Editor)

DOI: 10.1007/s11883-011-0207-y

Cite this article as:
Siri-Tarino, P.W. Curr Atheroscler Rep (2011) 13: 453. doi:10.1007/s11883-011-0207-y


Multiple dietary factors have been shown to increase high-density lipoprotein cholesterol (HDL-C) concentrations, and HDL-C has been inversely associated with coronary heart disease (CHD) risk. Replacement of dietary carbohydrate with polyunsaturated, monounsaturated and saturated fat has been associated with progressively greater increases in HDL-C (7–12%) in addition to other lipid changes. Added sugars, but not high glycemic carbohydrates, have been associated with decreased HDL-C. Alcohol consumption has been associated with increased HDL-C (9.2%) independent of changes in other measured lipids. Modest effects on HDL-C (~4–5%) among other lipid and non-lipid CHD risk factors have also been observed with weight loss by dieting, omega-3 fatty acids, and a Mediterranean diet pattern. The CHD benefit of increasing HDL-C is unclear given the inconsistent evidence from HDL-raising pharmacologic trials. Furthermore, pleiotropic effects of diet preclude attribution of CHD benefit specifically to HDL-C. Investigation into functional or other properties of HDL may lend further insight.


DietHDL cholesterolHDL-CCoronary heart diseaseCarbohydrateFatPolyunsaturated fatMonounsaturated fatSaturated fatTriglycerideDyslipidemiaObesityWeight lossAlcoholMediterranean dietOmega 3 fatty acidsFishCholesterol efflux

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Atherosclerosis ResearchChildren’s Hospital Oakland Research InstituteOaklandUSA