Current Atherosclerosis Reports

, Volume 12, Issue 5, pp 301–307

Lessons from Coronary Intravascular Ultrasound on the Importance of Raising High-Density Lipoprotein Cholesterol

Authors

    • Department of Cardiovascular Medicine, Heart & Vascular InstituteCleveland Clinic
    • Cell BiologyCleveland Clinic
    • Center for Cardiovascular Diagnostics and PreventionCleveland Clinic
  • Kiyoko Uno
    • Department of Cardiovascular Medicine, Heart & Vascular InstituteCleveland Clinic
  • E. Murat Tuzcu
    • Department of Cardiovascular Medicine, Heart & Vascular InstituteCleveland Clinic
  • Steven E. Nissen
    • Department of Cardiovascular Medicine, Heart & Vascular InstituteCleveland Clinic
Article

DOI: 10.1007/s11883-010-0125-4

Cite this article as:
Nicholls, S.J., Uno, K., Tuzcu, E.M. et al. Curr Atheroscler Rep (2010) 12: 301. doi:10.1007/s11883-010-0125-4
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Abstract

Technological advances have enhanced our ability to visualize the entire extent of atherosclerosis within the artery wall. Intravascular ultrasound has enabled characterization of the impact of medical therapies on progression of coronary atherosclerosis. Despite use of established anti-atherosclerotic therapy, cardiovascular disease still remains the leading cause of morbidity and mortality. There is an ongoing need to develop new therapeutic strategies to achieve more effective reduction in cardiovascular risk. Raising high-density lipoprotein cholesterol continues to receive attention as a therapeutic strategy. The relationship between high-density lipoprotein and progression of atherosclerosis and its implications for clinical practice are reviewed here.

Keywords

HDLIntravascular ultrasoundRisk factorsImagingAtherosclerosis

Copyright information

© Springer Science+Business Media, LLC 2010