Current Atherosclerosis Reports

, Volume 12, Issue 3, pp 194–201

Lipidomics as a Tool for the Study of Lipoprotein Metabolism

Article

DOI: 10.1007/s11883-010-0100-0

Cite this article as:
Kontush, A. & Chapman, M.J. Curr Atheroscler Rep (2010) 12: 194. doi:10.1007/s11883-010-0100-0

Abstract

Although technologies for lipidomic and proteomic investigations have developed very recently, lipidomic and proteomic studies of plasma lipoproteins have already provided several impressive examples of detailed characterization of distinct metabolic pathways potentially involved in lipoprotein metabolism in both health and disease states (obesity, insulin resistance, fatty liver disease) as well as under lifestyle and dietary modification (fish consumption, carbohydrates, probiotics) and lipid-modifying treatments (statins, low-density lipoprotein apheresis). Available lipidomic methodologies have facilitated detailed characterization of lipid classes and molecular species present in plasma as well as in lipoprotein fractions. Together with emerging proteomic techniques, lipidomics of plasma lipoproteins will soon provide molecular details of lipoprotein composition, which will ultimately be translated into integrated knowledge of the structure, metabolism, and function of lipoproteins in health and disease.

Keywords

LipidomePlasmaLipoproteinsLipidsVLDLLDLHDL

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Université Pierre et Marie Curie-Paris 6ParisFrance
  2. 2.AP-HPGroupe hospitalier Pitié-SalpétrièreParisFrance
  3. 3.Dyslipidemia, Inflammation and Atherosclerosis Research Unit (UMR 939)National Institute for Health and Medical Research (INSERM)ParisFrance
  4. 4.INSERM Unit 939, Pavillon Benjamin DelessertHôpital de la PitiéParisFrance