Saturated and trans fatty acids and coronary heart disease
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Dietary intake of both saturated and trans fatty acids has been associated with an increase in the risk of coronary heart disease (CHD). Evidence comes mainly from controlled dietary experiments with intermediate end points, such as blood lipoproteins, and from observational studies. A few small, randomized controlled trials with clinical end points have been carried out in which saturated fat was replaced with polyunsaturated fat, leading to a reduction in low-density lipoprotein cholesterol and a reduction in CHD risk. However, no such studies exist for trans fatty acids. More high-quality, randomized controlled trials on fatty acids and CHD are required, but public health recommendations to reduce intake of both saturated and trans fatty acids are appropriate based on the current evidence.
- Mann JI: Diet and risk of coronary heart disease and type 2 diabetes. Lancet 2002, 360:783–789. CrossRef
- Keys A, Parlin RW: Serum cholesterol response to changes in dietary lipids. Am J Clin Nutr 1966, 19:175–181.
- Hegsted DM, McGandy RB, Myers ML, Stare FJ: Quantitative effects of dietary fat on serum cholesterol in man. Am J Clin Nutr 1965, 17:281–295.
- Mensink RP, Zock PL, Kester AD, Katan MB: Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am J Clin Nutr 2003, 77:1146–1155.
- Sacks FM, Katan M: Randomised clinical trials on the effects of dietary fat and carbohydrate on plasma lipoproteins and cardiovascular disease. Am J Med 2002, 113:13S–24S. CrossRef
- Appel LJ, Sacks FM, Carey VJ, et al.: Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart Randomised Trial. JAMA 2005, 294:2455–2464. CrossRef
- Berglund L, Lefevre M, Ginsberg HN, et al.: Comparison of monounsaturated fat with carbohydrates as a replacement for saturated fat in subjects with a high metabolic risk profile: studies in the fasting and postprandial states. Am J Clin Nutr 2007, 86:1611–1620.
- Mensink RP: Metabolic and health effects of isomeric fatty acids. Curr Opin Lipidol 2005, 16:27–30. CrossRef
- Mozaffarian D, Katan MB, Ascherio A, et al.: Trans fatty acids and cardiovascular disease. N Engl J Med 2006, 354:1601–1613. CrossRef
- Ascherio A, Katan MB, Zock PL, et al.: Trans fatty acids and coronary heart disease. N Engl J Med 1999, 340:1994–1998. CrossRef
- Krauss RM, Eckel RH, Howard B, et al.: AHA Dietary Guidelines: revision 2000: A statement for healthcare professionals from the Nutrition Committee of the American Heart Association. Circulation 2000, 102:2284–2299.
- Jenkins DJ, Kendall CW, Marchie A, et al.: Effects of a dietary portfolio of cholesterol-lowering foods vs lovastatin on serum lipids and C-reactive protein. JAMA 2003, 290:502–510. CrossRef
- Kris-Etherton P, Daniels SR, Eckel RH, et al.: Summary of the Scientific Conference on Dietary Fatty Acids and Cardiovascular Health. Conference Summary from the Nutrition Committee of the American Heart Association. Circulation 2001, 103:1030–1039.
- Hu FB, Willett WC: Optimal diets for prevention of coronary heart disease. JAMA 2002, 288:2569–2578. CrossRef
- Turpeinen AM, Wubert J, Aro A, et al.: Similar effects of diets rich in stearic acid or trans-fatty acids on platelet function and endothelial prostacyclin production in humans. Arterioscler Thromb Vasc Biol 1998, 18:316–322.
- Keogh JB, Grieger JA, Noakes M, Clifton PM: Flow-mediated dilatation is impaired by a high-saturated fat diet but not by a high-carbohydrate diet. Arterioscler Thromb Vasc Biol 2005, 25:1274–1279. CrossRef
- Keogh JB, Brinkworth GD, Noakes M, et al.: Effects of weight loss from a very-low-carbohydrate diet on endothelial function and markers of cardiovascular disease risk in subjects with abdominal obesity. Am J Clin Nutr 2008, 87:567–576.
- de Roos NM, Bots ML, Katan MB: Replacement of dietary saturated fatty acids by trans fatty acids lowers serum HDL cholesterol and impairs endothelial function in healthy men and women. Arterioscler Thromb Vasc Biol 2001, 21:1233–1237. CrossRef
- Lopez-Garcia E, Schulze MB, Meigs JB, et al.: Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction. J Nutr 2005, 135:562–566.
- Mozaffarian D, Pischon T, Hankinson SE, et al.: Dietary intake of trans fatty acids and systemic inflammation in women. Am J Clin Nutr 2004, 79:606–612.
- Han SN, Leka LS, Lichtenstein AH, et al.: Effect of hydrogenated and saturated, relative to polyunsaturated, fat on immune and inflammatory responses of adults with moderate hypercholesterolemia. J Lipid Res 2002, 43:445–452.
- Baer DJ, Judd JT, Clevidence BA, et al.: Dietary fatty acids affect plasma markers of inflammation in healthy men fed controlled diets: a randomized crossover study. Am J Clin Nutr 2004, 79:969–973.
- Lichtenstein AH, Erkkila AT, Lamarche B, et al.: Influence of hydrogenated fat and butter on CVD risk factors: remnant-like particles, glucose and insulin, blood pressure and C-reactive protein. Atherosclerosis 2003, 171:97–107. CrossRef
- Kuhnt K, Kraft J, Vogelsang H, et al.: Dietary supplementation with trans-11-and trans-12-18:1 increases cis-9, trans-11-conjugated linoleic acid in human immune cells, but without effects on biomarkers of immune function and inflammation. Br J Nutr 2007, 97:1196–1205. CrossRef
- Rasmussen BM, Vessby B, Uusitupa M, et al.: Effects of dietary saturated, monounsaturated, and n-3 fatty acids on blood pressure in healthy subjects. Am J Clin Nutr 2006, 83:221–226.
- Kato H, Tillotson J, Nichaman MZ, et al.: Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California. Am J Epidemiol 1973, 97:372–385.
- Kromhout D, Menotti A, Bloemberg B, et al.: Dietary saturated and trans fatty acids and cholesterol and 25-year mortality from coronary heart disease: the Seven Countries Study. Prev Med 1995, 24:308–315. CrossRef
- McGee DL, Reed DM, Yano K, et al.: Ten-year incidence of coronary heart disease in the Honolulu Heart Program. Relationship to nutrient intake. Am J Epidemiol 1984, 119:667–676.
- Kushi LH, Lew RA, Stare FJ, et al.: Diet and 20-year mortality from coronary heart disease. The Ireland-Boston Diet-Heart Study. N Engl J Med 1985, 312:811–818.
- Hu FB, Manson JE, Willett WC: Types of dietary fat and risk of coronary heart disease: a critical review. J Am Coll Nutr 2001, 20:5–19.
- Hu FB, Stampfer MJ, Manson JE, et al.: Dietary fat intake and the risk of coronary heart disease in women. N Engl J Med 1997, 337:1491–1499. CrossRef
- Oh K, Hu FB, Manson JE, et al.: Dietary fat intake and risk of coronary heart disease in women: 20 years of follow-up of the Nurses’ Health Study. Am J Epidemiol 2005, 161:672–679. CrossRef
- Xu J, Eilat-Adar S, Loria C, et al.: Dietary fat intake and risk of coronary heart disease: the Strong Heart Study. Am J Clin Nutr 2006, 84:894–902.
- Oomen CM, Ocke MC, Feskens EJ, et al.: Association between trans fatty acid intake and 10-year risk of coronary heart disease in the Zutphen Elderly Study: a prospective population-based study. Lancet 2001, 357:746–751. CrossRef
- Sun Q, Ma J, Campos H, et al.: A prospective study of trans fatty acids in erythrocytes and risk of coronary heart disease. Circulation 2007, 115:1858–1865. CrossRef
- Truswell AS: Review of dietary intervention studies: effect on coronary events and on total mortality. Aust NZ J Med 1994, 24:98–106.
- Appel LJ, Moore TJ, Obarzanek E, et al.: A clinical trial of the effects of dietary patterns on blood pressure. N Engl J Med 1997, 336:1117–1124. CrossRef
- Fung TT, Chiuve SE, McCullough ML, et al.: Adherence to a DASH-style diet and risk of coronary heart disease and stroke in women. Arch Intern Med 2008, 168:713–720. CrossRef
- de Lorgeril M, Salen P, Martin JL, et al.: Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction. Final report of the Lyon Diet Heart Study. Circulation 1999, 99:779–785.
- de Lorgeril M, Renaud S, Mamelle N, et al.: Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet 1994, 343:1454–1459. CrossRef
- Howard BV, Van Horn L, Hsia J, et al.: Low-fat dietary pattern and risk of cardiovascular disease. The Women’s Health Initiative Randomised Controlled Dietary Modification Trial. JAMA 2006, 295:655–666. CrossRef
- Gebauer SK, Psota TL, Kris-Etherton PM: The diversity of health effects of individual trans fatty acid isomers. Lipids 2007, 42:787–799. CrossRef
- Jakobsen MU, Overvad K, Dyerberg J, Heitmann BL: Intake of ruminant trans fatty acids and risk of coronary heart disease. Int J Epidemiol 2008, 37:173–182. CrossRef
- Willett W, Mozaffarian D: Ruminant or industrial sources of trans fatty acids: public health issue or food label skirmish? Am J Clin Nutr 2008, 87:515–516.
- Chardigny JM, Destaillats F, Malpuech-Brugere C, et al.: Do trans fatty acids from industrially produced sources and from natural sources have the same effect on cardiovascular disease risk factors in healthy subjects? Results of the trans fatty acids collaboration (TRANSFACT) study. Am J Clin Nutr 2008, 87:558–566.
- Motard-Belanger A, Charest A, Grenier G, et al.: Study of the effect of trans fatty acids from ruminants on blood lipids and other risk factors for cardiovascular disease. Am J Clin Nutr 2008, 87:593–599.
- Colon-Ramos U, Baylin A, Campos H: The relation between trans fatty acid levels and increased risk of myocardial infarction does not hold at lower levels of trans fatty acids in the Costa Rican food supply. J Nutr 2006, 136:2887–2892.
- Lefevre M, Champagne CM, Tulley RT, et al.: Individual variability in cardiovascular disease risk factors responses to low-fat and low-saturated-fat diets in men: body mass index, adiposity, and insulin resistance predict changes in LDL cholesterol. Am J Clin Nutr 2005, 82:957–963.
- Minihane AM, Lofre-Monseny L, Olano-Martin E, Rimbach G: ApoE genotype, cardiovascular risk and responsiveness to dietary fat manipulation. Proc Nutr Soc 2007, 66:183–197. CrossRef
- World Health Organization: Diet, Nutrition and Prevention of Chronic Diseases. Report of a WHO/FAO Export Consultation. Technical report series 916. Geneva, Switzerland: WHO; 2003.
- Mozaffarian D, Abdollahi M, Campos H, et al.: Consumption of trans fats and estimated effects on coronary heart disease in Iran. Eur J Clin Nutr 2007, 61:1004–1010. CrossRef
- Lee S, Harnack L, Jacobs DR, et al.: Trends in diet quality for coronary heart disease prevention between 1980–1982 and 2000–2002: the Minnesota Heart Survey. J Am Diet Assoc 2007, 107:213–222. CrossRef
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