Current Atherosclerosis Reports

, Volume 9, Issue 3, pp 230–237

Transcriptional regulation of peroxisome proliferator-activated receptors and liver X receptors

  • Luis Villacorta
  • Minerva T. Garcia-Barrio
  • Yuqing E. Chen
Article

DOI: 10.1007/s11883-007-0024-5

Cite this article as:
Villacorta, L., Garcia-Barrio, M.T. & Chen, Y.E. Curr Atheroscler Rep (2007) 9: 230. doi:10.1007/s11883-007-0024-5

Abstract

Peroxisome proliferator-activated receptors (PPAR) and liver X receptors (LXR) regulate a plethora of biologic processes and key metabolic and physiologic events. Deregulation of their transcription and activity is commonly associated with dyslipidemic disorders, diabetes, cancer, and cardiovascular disease. This review addresses recent advances in our understanding of the molecular mechanisms regulating transcription of these nuclear receptors. The heterogeneity of factors regulating their transcription and activity suggests intricate regulatory networks that determine their tissue expression pattern and their responses to pharmacologic agents. Understanding such mechanisms will facilitate unraveling their protective effects in disease as well as the design of effective targeted therapies.

Copyright information

© Current Medicine Group LLC 2007

Authors and Affiliations

  • Luis Villacorta
  • Minerva T. Garcia-Barrio
  • Yuqing E. Chen
    • 1
  1. 1.Cardiovascular Center, Department of Internal MedicineUniversity of Michigan Medical CenterAnn ArborUSA