Current Atherosclerosis Reports

, Volume 8, Issue 4, pp 304–309

Hemostatic therapy for intracerebral hemorrhage

  • Fred Rincon
  • Manuel M. Buitrago
  • Stephan A. Mayer

DOI: 10.1007/s11883-006-0008-x

Cite this article as:
Rincon, F., Buitrago, M.M. & Mayer, S.A. Curr Atheroscler Rep (2006) 8: 304. doi:10.1007/s11883-006-0008-x


Despite the highest mortality and morbidity of all forms of stroke, few advances have been made in the management of intracerebral hemorrhage (ICH). Besides specialized care in the stroke or neurologic intensive care unit, until very recently no specific therapies have been shown to improve outcome after ICH. Ventilatory support, blood pressure reduction, intracranial pressure monitoring, osmotherapy, fever control, seizure prophylaxis, and nutritional supplementation are the cornerstones of supportive care in the intensive care unit. Recently, a phase II trial of recombinant activated factor VII (NovoSeven; Novo Nordisk, Bagsvaerd, Denmark) reduced hematoma expansion, mortality, and disability when given within 3 hours of ICH onset. A phase III trial to confirm these results is now in progress.

Copyright information

© Current Science Inc 2006

Authors and Affiliations

  • Fred Rincon
  • Manuel M. Buitrago
  • Stephan A. Mayer
    • 1
  1. 1.Division of Critical Care NeurologyNeurological InstituteNew YorkUSA