Current Atherosclerosis Reports

, Volume 6, Issue 5, pp 359–365

High-density lipoprotein subfractions and risk of coronary artery disease

  • John Morgan
  • Christina Carey
  • Anne Lincoff
  • David Capuzzi
Article

DOI: 10.1007/s11883-004-0047-0

Cite this article as:
Morgan, J., Carey, C., Lincoff, A. et al. Curr Atheroscler Rep (2004) 6: 359. doi:10.1007/s11883-004-0047-0

Abstract

Numerous studies have shown that levels of high-density lipoprotein (HDL) cholesterol are inversely related to coronary artery disease risk. The HDL subfractions, however, seem to differ in their capacity to confer protection, with the large HDL2 subfraction appearing to be more important than the small HDL3 subfraction. Lipid-modifying drugs differ in their HDL-raising efficacy, and they also differ in how they affect HDL subfractions. Clinical trials show that raising total HDL cholesterol improves clinical and angiographic outcomes. It remains to be determined, however, whether a shift in distribution of HDL particles provides greater benefit than just an increase in total HDL.

Copyright information

© Current Science Inc 2004

Authors and Affiliations

  • John Morgan
    • 1
  • Christina Carey
  • Anne Lincoff
  • David Capuzzi
  1. 1.Sidney Kimmel Laboratory for Preventive CardiologyThomas Jefferson University - Jefferson Heart InstitutePhiladelphiaUSA