Genetics of eating and its relation to obesity
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Humans show remarkable variability in their eating styles. Reasons for this variability are poorly understood, but carry important implications for the onset of obesity and its comorbidities. Although it is well established that genes influence obesity, genetic influences on human eating patterns have received less attention. Dramatic increases in the prevalence of obesity justify additional research into the genetics of eating style. This review highlights what is known about the genetics of food preferences and selection in humans. Data from family and twin studies suggest a moderate genetic contribution to eating style, with clear environmental effects emerging as well. Select studies show support for gene-environment interactions and common genetic bases for certain dietary patterns, obesity, and/or metabolic complications. Genetically informative designs that infuse innovative behavioral measures may help explain individual differences in eating styles and hopefully promote more effective obesity treatments.
- Flegal MD, Carroll RJ, Kuczmarski RJ, et al.: Overweight and obesity in the United States: prevalence and trends, 1960–1994. Int J Obes Relat Metab Disord, 1998, 22:39–47. CrossRef
- Pi-Sunyer FX: Medical hazards of obesity. Ann Intern Med 1993, 119:655–660.
- Comuzzie AG, Allison DB: The search for human obesity genes. Science 1998, 280:1374–1377. CrossRef
- Faith MS, Johnson SL, Allison DB: Putting the “behavior” into the behavior genetics of obesity research. Behav Genet 1997, 27:423–439. CrossRef
- Neale MC, Cardon LR: Methodology for Genetic Studies of Twins and Families. Boston: Kluwer Press; 1992.
- Heitmann BL, Lissner L, Sorenson TI, et al.: Dietary fat intake and weight gain in women genetically predisposed for obesity. Am J Clin Nutr, 1995, 61:1213–1217.
- Lissner L, Heitmann BL: Dietary fat and obesity: evidence from epidemiology. Eur J of Clin Nutr 1995, 49:79–90.
- Lissner L, Heitmann BL, Bengtsson C: Population studies of diet and obesity. Br J Nutr 2000, 83:S21-S24.
- Bengtsson C, Bjorkelund C, Lapidus L, et al.: Association of serum lipid concentrations and obesity with mortality in women—20 year follow up of participants in the prospective population study in Gothenburg, Sweden. BMJ 1993, 307:1385–1388. CrossRef
- Bray GA, Popkin BM: Dietary fat intake does affect obesity. Am J Clin Nutr, 1998, 68:1157–1173.
- Fung TT, Willet WC, Stampfer MJ, et al.: Dietary patterns and the risk for coronary heart disease in women. Arch Intern Med 2001, 161:1857–1862. CrossRef
- Kuller LH, Simkin-Silverman LR, Wing RR, et al.: Women’s Healthy Lifestyle Project: a randomized clinical trial: results at 54 months. Circulation, 2001, 103:32–37.
- Hunninghake DB, Stein EA, Dujovne CA, et al.: The efficacy of intensive dietary therapy alone or combined with lovastatin in outpatients with hypercholesterolemia. N Engl J Med, 1993, 328:1231–1239. CrossRef
- Kazim SE, Martino S, Kim PN, et al.: Dietary and anthropometric determinants of plasma lipoproteins during long-term low-fat diet in healthy women. Am J Clin Nutr 1993, 57:146–153.
- McGuffin P, Riley B, Plomin R: Toward behavioral genomics. Science 2001, 291:1232–1249. CrossRef
- Faith MS, Rha SS, Neale MC, et al.: Evidence for genetic influences on human energy intake: results from a twin study using measured observations. Behav Genet 1999, 29:145–154. CrossRef
- Plomin R, DeFries JC, McClean GE, Rutter M: Behavior Genetics. New York: WH Freeman; 1997.
- Lynch M, Walsh B: Genetics and Analysis of Quantitative Traits. Sunderland, MA: Sinauer Associates; 1998.
- Maes H, Neale MC, Eaves LJ: Genetic and environmental factors in relative body and human adiposity. Behav Genet 1997, 27:325–351. CrossRef
- Comuzzie AG, Williams JT, Martin LJ, Blangero J: Searching for genes underlying normal variation in human adiposity. J Molec Med 2001, 79:57–70. CrossRef
- deCastro JM: Behavioral genetics of food intake regulation in free-living humans. Nutrition 1999, 7/8:550–554. CrossRef
- van den Bree M, Eaves LJ, Dwyer JT: Genetic and environmental influences on eating patterns of twins aged > 50 y. Am J Clin Nutr 1999, 70:456–465.
- Wade J, Milner BA, Krondl M: Evidence for a physiological regulation of food selection and nutrient intake in twins. Am J Clin Nutr 1981, 34:143–147.
- Heller RF, O’Connell DL, Roberts DC: Lifestyle factors in monozygotic and dizygotic twins. Genet Epidemiol 1988, 5:311–321. CrossRef
- Rozin R, Millman L: Family environment, not heredity, accounts for family resemblance in food preferences and attitudes: a twin study. Appetite 1987, 8:125–134. CrossRef
- Johnson SL, McPhee L, Birch LL: Conditioned preferences: young children prefer flavors associated with high dietary fat. Physiol Behav 1991, 50:1245–1251. CrossRef
- Perusse L, Tremblay A, Leblanc C, et al.: Familial resemblance in energy intake: contribution of genetic and environmental factors. Am J Clin Nutr 1988, 47:629–635.
- Perusse L, Chagnon YC, Weisnagel J, et al.: The human obesity gene map: the 2000 update. Obes Res 2001, 9:136–168. CrossRef
- Reed DR, Bachmanov AA, Beauchamp GK: Heritable variation in food preferences and their contribution to obesity. Behav Genet 1997, 27:373–387. CrossRef
- Faciglia GA, Norton PA: Evidence for genetic influences on preference for some foods. J Am Diet Assoc 1994, 94:155–158.
- Harris H, Kalmus H: The measurement of taste sensitivity to phenylthiourea (PTC). Ann Eugenics 1949, 94:653–661.
- Tepper BJ: 6-n-propylthiouracil (PROP): a genetic marker for taste, with implications for food preference and dietary habits. Am J Hum Genet 1998, 63:1271–1276. CrossRef
- Bartoshuk LM, Duffy VB, Miller IJ: PTC/PROP tasting: anatomy, psychophysics and sex effects. Physiol Behav 1994, 56:1165–1171. CrossRef
- Drewnowski A, Henderson SA, Hann CS: Genetic taste markers and preferences for vegetables and fruit of female breast cancer patients. J Am Diet Assoc 2000, 100:197.
- Drewnowski A, Henderson SA, Shore AF: Taste responses to nariningin, a flavonoid, and the acceptance of grapefruit juice are related to genetic sensitivity to 6-n-propylthiouracil. Am J Clin Nutr 1997, 66:391–397.
- Fisher R, Griffin F, England S: Taste thresholds and food dislikes. Nature 1961, 191:320.
- Tepper BJ, Nurse RJ: Fat perception is related to PROP taster status. Physiol Behavi 1997, 61:949–954. CrossRef
- Tepper BJ, Nurse RJ: PROP taster status is related to fat perception and preference. Ann NY Acad Sci 1998, 855:802–804. CrossRef
- Duffy VB, Bartoshuk LM: Food acceptance and genetic variation in taste. J Am Diet Assoc 2000, 100:647–655. CrossRef
- Keller KL, Steinmann L, Nurse RJ, Tepper BJ: Genetic sensitivity to 6-n-propylthiouracil (PROP) influences food preferences and reported intake in preschool children. Appetite 2002, in press.
- Perusse L, Bouchard C: Gene-diet interactions in obesity. Am J Clin Nutr 2000, 72:1285S-1290S.
- Bouchard C, Tremblay A, Despres JP, et al.: The response to long-term overfeeding in identical twins. N Engl J Med 1990, 322:1477–1482. CrossRef
- Ukkola C, Bouchard C: Clustering of metabolic abnormalities in obese individuals: the role of genetic factors. Ann Med 2001, 33:79–90.
- McCaffery JM, Pogue-Geile MF, Muldoon MF, et al.: The nature of the association between diet and serum lipids in the community: a twin study. Health Psychol 2001, 20:341–350. CrossRef
- Prader A, Labhart A, Willi H: Syndrome von adipositas, kleinwucs, kryptorchidismus and oligophrenia nach hyatonieartigen zustand in neugeborenenalter. Schweiz Med Wochenschr 1956, 86:1260–1261.
- Holland AJ, Teasure J, Coskeran P, Dallow J: Characteristics of the eating disorder in Prader-Willi syndrome: implications for treatment. J Intellect Disabil Res 1995, 39:373–381. CrossRef
- Katsanis N, Beales PL, Woods MO, et al.: Mutations in MKKS cause obesity, retinal dystrophy and renal malformations associated with Bardet-Biedle syndrome. Nature Genet 2000, 26:67–70. CrossRef
- Tahvanainen E, Norio R, Karila E: Cohen syndrome gene assigned to the long arm of chromosome 8 by a linkage analysis. Nature Genet 1994, 7:201–204. CrossRef
- Allison DB, Packer-Munter W, Pietrobelli A, Alfonso VC, Faith MS: Obesity and developmental disabilities: pathogenesis and treatment. J Develop Phys Disabil 1998, 10:215–255. CrossRef
- Holder JL Jr, Butte NF, Zinn AR: Profound obesity associated with a balanced translocation that disrupts the SIM1 gene. Hum Mol Genet 2000, 9:101–108. CrossRef
- Montague CT, Farooqi IS, Whitehead JP, et al.: Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997, 387:903–908. CrossRef
- Farooqi IS, Jebb SA, Langmack G, et al.: Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 1999, 341:879–884. CrossRef
- deCastro JM: Genetic influences on daily intake and meal patterns of humans. Physiol Behav 1993, 53:777–782. CrossRef
- Genetics of eating and its relation to obesity
Current Atherosclerosis Reports
Volume 4, Issue 3 , pp 176-182
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- 1. New York Obesity Research Center, St. Luke’s-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, 1090 Amsterdam Avenue, 14th Floor, 10025, New York, NY, USA