Article

Current Atherosclerosis Reports

, Volume 3, Issue 3, pp 252-259

First online:

Atherogenesis and the arginine hypothesis

  • John P. CookeAffiliated withSection of Vascular Medicine, Stanford University School of Medicine
  • , Roberta K. OkaAffiliated withSection of Vascular Medicine, Stanford University School of Medicine

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Abstract

In patients who have elevated levels of plasma ADMA, a relative deficiency of L-arginine has been found to contribute to the pathophysiology of athersclerosis, causing vasoconstriction, and accelerating atherogenesis. This finding—that there is a relative deficiency of L-arginine in atherosclerotic disease—is a breakthrough that will open new avenues of therapy.