Gene-diet interaction and plasma lipid response to dietary intervention
- Jose M. Ordovas PhD
- … show all 1 hide
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
Research in the field of gene-diet interactions as determinants of plasma lipid response to dietary interventions has accumulated a substantial body of evidence during the past decade. Several candidate genes have shown some promise as potential markers of individual dietary responsiveness. Among the best characterized are the APOE, APOA4, APOB, APOC3, and LPL loci. Other genes are being continuously incorporated to this most interesting search. However, in very few cases has consensus been achieved about the usefulness of genetic markers as clinically significant predictors of dietary response. The increased ability to generate genotypic information, in combination with the knowledge from the human genome project and more comprehensive experimental designs, will dramatically improve our capacity to answer many of our current questions. It will also help to prove that knowledge of an individual’s genetic background will facilitate more precise dietary counseling and intervention, and more efficacious primary and secondary coronary heart disease prevention.
- Venter CJ, Adams MD, Myers EW, et al.: The sequence of the human genome. Science 2001, 291:1304–1351. CrossRef
- Human Genome Sequenting Consortium. Initial sequencing and analysis of the human genome. Nature 2001, 409:860–921.
- Expert Panel on High Blood Pressure and Cholesterol in Adults. Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II). JAMA 1993, 269:3015–3023.
- Keys A, Anderson JT, Grande F: “Essential” fatty acids, degree of unsaturation, and effect of corn oil on the serum cholesterol level in man. Lancet, 1957, 1:66–68. CrossRef
- Ahrens EH: Nutritional factors and serum lipid levels. Am J Med 1957, 23:928–952. CrossRef
- Keys A, Anderson JT, Grande F: Prediction of serum cholesterol responses of man to changes in fats in the diet. Lancet, 1957, 2:959–966. CrossRef
- Hegsted DM, McGandy RB, Myers ML, Stare FJ: Quantitative effects of dietary fat on serum cholesterol in man. Am J Clin Nutr 1965, 17:281–295.
- Hegsted DM, Ausman LM, Johnson JA, Dallal GE: Dietary fat and serum lipids: an evaluation of the experimental data. Am J Clin Nutr 1993, 57:875–883.
- Mensink RP, Katan MB: Effect of dietary fatty acids on serum lipids and lipoproteins: a meta-analysis of 27 trials. Arterioscler Thromb 1992, 12:911–919.
- Cobb MM, Teitlebaum H: Determinants of plasma cholesterol responsiveness to diet. Br J Nutr 1994, 71:271–282. CrossRef
- Okey R, Stewart D: Diet and blood cholesterol in normal women. J Biol Chem 1933, 99:717–727.
- Katan MB, Beynen AC, de Vries JH, Nobels A: Existence of consistent hypo- and hyperresponders to dietary cholesterol in man. Am J Epidemiol 1986, 123:221–234.
- Jacobs DR, Anderson JT, Hannan P, et al.: Variability in individual serum cholesterol response to change in diet. Arteriosclerosis 1983, 3:349–356.
- Cobb MM, Risch N: Low-density lipoprotein cholesterol responsiveness to diet in normolipidemic subjects. Metabolism 1993, 42:7–13. CrossRef
- O’Hanesian MA, Rosner B, Bishop LM, Sacks FM: Effects of inherent responsiveness to diet and day-to-day diet variation on plasma lipoprotein concentrations. Am J Clin Nutr 1996, 64:53–59.
- Schaefer EJ, Lichtenstein AH, Lamon-Fava S, et al.: Efficacy of a National Cholesterol Education Program Step 2 diet in normolipidemic and hypercholesterolemic middle-aged and elderly men and women. Arterioscler Thromb Vasc Biol 1995, 15:1079–1085.
- Mahaney MC, Blangero J, Rainwater DL, et al.: Pleiotropy and genotype by diet interaction in a baboon model for atherosclerosis: a multivariate quantitative genetic analysis of HDL subfractions in two dietary environments. Arterioscler Thromb Vasc Biol 1999, 19:1134–1141.
- Rainwater DL, Kammerer CM, Hixson JE, et al.: Two major loci control variation in beta-lipoprotein cholesterol and response to dietary fat and cholesterol in baboons. Arterioscler Thromb Vasc Biol 1998, 18:1061–1068.
- Deckelbaum RJ, Fisher EA, Winston M, et al.: Summary of a scientific conference on preventive nutrition: pediatrics to geriatrics. Circulation 1999, 100:450–456.
- Krauss RM, Eckel RH, Howard BV, et al.: AHA Dietary Guidelines: Revision 2000: A Statement for Healthcare Professionals From the Nutrition Committee of the American Heart Association. Circulation 2000, 102:2284–2299.
- Ordovas J, Galluzzi JR: Genetic predictors of plasma lipid response to diet intervention. Curr Atherosclerosis Rep 1999, 1:196–203.
- Weggemans RM, Zock PL, Meyboom S, et al.: Apolipoprotein A4-1/2 polymorphism and response of serum lipids to dietary cholesterol in humans. J Lipid Res 2000, 41:1623–1628.
- Ostos MA, Lopez-Miranda J, Marin C, et al.: The apolipoprotein A-IV-360His polymorphism determines the dietary fat clearance in normal subjects. Atherosclerosis 2000, 153:209–217. CrossRef
- Heilbronn LK, Noakes M, Morris AM, et al.: 360His polymorphism of the apolipoproteinA-IV gene and plasma lipid response to energy restricted diets in overweight subjects. Atherosclerosis 2000, 150:187–192. CrossRef
- Mata P, Ordovas JM, Lopez-Miranda J, et al.: ApoA-IV phenotype affects diet-induced plasma LDL cholesterol lowering. Arterioscler Thromb 1994, 14:884–891.
- McCombs RJ, Marcadis DE, Ellis J, Weinberg RB: Attenuated hypercholesterolemic response to a high-cholesterol diet in subjects heterozygous for the apolipoprotein A-IV- 2 allele. N Engl J Med 1994, 331:706–710. CrossRef
- Jansen S, Lopez-Miranda J, Salas J, et al.: Plasma lipid response to hypolipidemic diets in young healthy non-obese men varies with body mass index. J Nutr 1998, 128:1144–1149.
- Denke MA, Adams-Huet B, Nguyen AT: Individual cholesterol variation in response to a margarine- or butter-based diet. JAMA 2000, 284:2740–2747. CrossRef
- Loktionov A, Scollen S, McKeown N, Bingham SA: Gene-nutrient interactions: dietary behaviour associated with high coronary heart disease risk particularly affects serum LDL cholesterol in apolipoprotein E epsilon4-carrying free-living individuals. Br J Nutr 2000, 84:885–890.
- Lehtimäki T, Moilanen T, Porkka K, et al.: Association between serum lipids and apolipoprotein E phenotype is influenced by diet in a population-based sample of free- living children and young adults: the Cardiovascular Risk in Young Finns Study. J Lipid Res 1995, 36:653–661.
- Kauma H, Savolainen MJ, Rantala AO, et al.: Apolipoprotein E phenotype determines the effect of alcohol on blood pressure in middle-aged men. Am J Hypertens 1998, 11:1334–1343. CrossRef
- Campos H, D’Agostino M, Ordovas JM: Gene-diet interactions and plasma lipoproteins: role of apolipoprotein E and habitual saturated fat intake. Genet Epidemiol 2001, 20:117–128. CrossRef
- Corella D, Tucker K, Lahoz C, et al.: Alcohol drinking determines the effect of the APOE locus on LDL-cholesterol concentrations in men: the Framingham Offspring Study. Am J Clin Nutr 2001, in press.
- Friedlander Y, Leitersdorf E, Vecsler R, et al.: The contribution of candidate genes to the response of plasma lipids and lipoproteins to dietary challenge. Atherosclerosis 2000, 152:239–248. CrossRef
- Kee F, Young IS, Poirier O, et al.: Do polymorphisms of apoB, LPL or apoE affect the hypocholesterolemic response to weight loss? Atherosclerosis 2001, 153:119–128. CrossRef
- Kuivenhoven JA, Jukema JW, Zwinderman AH, et al.: The role of a common variant of the cholesteryl ester transfer protein gene in the progression of coronary atherosclerosis. The Regression Growth Evaluation Statin Study Group. N Engl J Med 1998, 338:86–93. CrossRef
- Dullaart RP, Hoogenberg K, Riemens SC, et al.: Cholesteryl ester transfer protein gene polymorphism is a determinant of HDL cholesterol and of the lipoprotein response to a lipid-lowering diet in type 1 diabetes. Diabetes 1997, 46:2082–2087. CrossRef
- Wallace AJ, Mann JI, Sutherland WH, et al.: Variants in the cholesterol ester transfer protein and lipoprotein lipase genes are predictors of plasma cholesterol response to dietary change. Atherosclerosis 2000, 152:327–336. CrossRef
- Lopez-Miranda J, Marin C, Castro P, et al.: The effect of apolipoprotein B xbaI polymorphism on plasma lipid response to dietary fat. Eur J Clin Invest 2000, 30:678–684. CrossRef
- Rantala M, Rantala TT, Savolainen MJ, et al.: Apolipoprotein B gene polymorphisms and serum lipids: meta-analysis of the role of genetic variation in responsiveness to diet. Am J Clin Nutr 2000, 71:713–724.
- Hegele RA, Wolever TM, Story A, et al.: Intestinal fatty acid binding protein variation associated with variation in the response of plasma lipoproteins to dietary fibre. Eur J Clin Invest 1997, 27:857–862. CrossRef
- Agren JJ, Valve R, Vidgren H, et al.: Postprandial lipiemic response is modified by the polymorphism at codon 54 of the fatty acid-binding protein 2 gene. Arterioscler Thromb Vasc Biol 1998, 18:1606–1610.
- Georgopoulos A, Aras O, Tsai MY: Codon-54 polymorphism of the fatty acid-binding protein 2 gene is associated with elevation of fasting and postprandial triglyceride in type 2 diabetes. J Clin Endocrinol Metab 2000, 85:3155–3160. CrossRef
- Krauss RM: Atherogenic lipoprotein phenotype and diet-gene interactions. J Nutr 2001, 131:340S-343S.
- Dreon DM, Fernstrom HA, Williams PT, Krauss RM: Reduced LDL particle size in children consuming a very-low-fat diet is related to parental LDL-subclass patterns. Am J Clin Nutr 2001, 71:1611–1616.
- Lee MH, Lu K, Hazard S, et al.: Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption. Nature Genet 2001, 27:79–83. CrossRef
- Perusse L, Bouchard C: Gene-diet interactions in obesity. Am J Clin Nutr 2000, 72:1285–1290.
- Aubert R, Betoulle D, Herberth B, et al.: 5-HT2A receptor gene polymorphism is associated with food and alcohol intake in obese people. Intl J Obes 2000, 24:920–924. CrossRef
- Couch SC, Cross AT, Kida K, et al.: Rapid westernization of children’s blood cholesterol in 3 countries: evidence for nutrient-gene interactions? Am J Clin Nutr 2000, 72:1266S-1274S.
- Tan CE, Emmanuel SC, Tan BY, Jacob E: Prevalence of diabetes and ethnic differences in cardiovascular risk factors. The 1992 Singapore National Health Survey. Diabetes Care 1999, 22:241–247. CrossRef
- Mouzeyan A, Choi J, Allayee H, et al.: A locus conferring resistance to diet-induced hypercholesterolemia and atherosclerosis on mouse chromosome 2. J Lipid Res 2000, 41:573–582.
- Stoehr JP, Nadler ST, Schueler KL, et al.: Genetic obesity unmasks nonlinear interactions between murine type 2 diabetes susceptibility loci. Diabetes 2000, 49:1946–1954. CrossRef
- Knoblauch H, Schuster H, Luft FC, Reichard PG: A pathway model of lipid metabolism to predict the effect of genetic variability on lipid levels. J Mol Med 2000, 78:507–515. CrossRef
- Gene-diet interaction and plasma lipid response to dietary intervention
Current Atherosclerosis Reports
Volume 3, Issue 3 , pp 200-208
- Cover Date
- Print ISSN
- Online ISSN
- Current Medicine Group
- Additional Links
- Author Affiliations
- 1. JM-USDA-Human Nutrition Research Center on Aging, Tufts University School of Medicine, 711 Washington Street, 02111, Boston, MA, USA