Current Atherosclerosis Reports

, 2:407

The role of proteinases in angiogenesis, heart development, restenosis, atherosclerosis, myocardial ischemia, and stroke: Insights from genetic studies

  • Aernout Luttun
  • Mieke Dewerchin
  • Désiré Collen
  • Peter Carmeliet
Article

DOI: 10.1007/s11883-000-0079-z

Cite this article as:
Luttun, A., Dewerchin, M., Collen, D. et al. Curr Atheroscler Rep (2000) 2: 407. doi:10.1007/s11883-000-0079-z

Abstract

The development of novel gene technologies in mice has provided an elegant tool to identify gene products that are causally linked to certain physiologic processes as well as the pathogenesis of numerous disorders. Using these techniques, three major proteolytic systems — the plasminogen, the matrix metalloproteinase (MMP) and the coagulation systems — have been shown to be involved in cardiovascular diseases, which still constitute the leading cause of death in Western societies. This overview summarizes the role of these proteolytic systems in angiogenesis, arterial stenosis, allograft transplant stenosis, vein graft stenosis, atherosclerosis, myocardial infarction, cardiac development and ischemic stroke and discusses possible therapeutic implications.

Copyright information

© Current Science Inc 2000

Authors and Affiliations

  • Aernout Luttun
    • 1
  • Mieke Dewerchin
    • 1
  • Désiré Collen
    • 1
  • Peter Carmeliet
    • 1
  1. 1.Center for Transgene Technology and Gene TherapyUniversity of LeuvenLeuvenBelgium