Current Atherosclerosis Reports

, Volume 2, Issue 4, pp 303–307

Endothelial function as a therapeutic target in coronary artery disease

  • Niraj Sharma
  • Thomas C. Andrews
Article

DOI: 10.1007/s11883-000-0063-7

Cite this article as:
Sharma, N. & Andrews, T.C. Curr Atheroscler Rep (2000) 2: 303. doi:10.1007/s11883-000-0063-7

Abstract

In healthy individuals, endothelial cells regulate a host of functions including vasomotor tone, thrombosis/fibrinolysis, and cell-cell interactions. The development of endothelial dysfunction may be a common pathway by which cardiovascular risk factors impact plaque formation, growth, and rupture. Many pharmacologic and nonpharmacologic interventions known to decrease cardiovascular risk also improve endothelial function. For these reasons, some have suggested that improvement in endothelial function may be an important therapeutic target in the treatment of coronary artery disease.

Copyright information

© Current Science Inc 2000

Authors and Affiliations

  • Niraj Sharma
    • 1
  • Thomas C. Andrews
    • 1
  1. 1.Department of Medicine, Cardiovascular DivisionThe University of Texas Southwestern Medical Center at DallasDallasUSA