Microbiome Diversity and Asthma and Allergy Risk

  • Antje Legatzki
  • Barbara Rösler
  • Erika von Mutius
Allergies and the Environment (RL Miller, Section Editor)

DOI: 10.1007/s11882-014-0466-0

Cite this article as:
Legatzki, A., Rösler, B. & von Mutius, E. Curr Allergy Asthma Rep (2014) 14: 466. doi:10.1007/s11882-014-0466-0
Part of the following topical collections:
  1. Topical Collection on Allergies and the Environment

Abstract

The prevalence of asthma and allergy has been constantly increasing in Westernized countries in the last decades. Asthma and allergies are complex diseases with a local tissue inflammation that are determined by genetic and environmental factors. Because the commensal microflora is crucial to maintain inflammatory homeostasis and to induce immune regulation, the microbiome may play an important role for the development of allergic conditions. New techniques such as next-generation sequencing methods give the opportunity to explore the microbial community structure of the human body comprehensively. In this review, we will discuss the available literature concerning the human microbiota and asthma and allergy development and occurrence. The focus is on studies of the local microbiome of the place of inflammation, the gastrointestinal microbiome, and the influence of intrinsic factors relating to the host and extrinsic factors relating to the external environment on the microbiome.

Keywords

Asthma Allergy Microbiome 16S rRNA Gut Lower airways Environment Antibiotics Probiotics 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Antje Legatzki
    • 1
  • Barbara Rösler
    • 2
  • Erika von Mutius
    • 2
  1. 1.Dr von Hauner Children’s HospitalLudwig Maximilian UniversityMunichGermany
  2. 2.Dr von Hauner Children’s Hospital, Ludwig Maximilian UniversityComprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung ResearchMunichGermany