What Does Tympanostomy Tube Placement in Children Teach Us About the Association Between Atopic Conditions and Otitis Media?

OTITIS (DP SKONER, SECTION EDITOR)

DOI: 10.1007/s11882-014-0447-3

Cite this article as:
Juhn, Y.J. & Wi, CI. Curr Allergy Asthma Rep (2014) 14: 447. doi:10.1007/s11882-014-0447-3
Part of the following topical collections:
  1. Topical Collection on Otitis

Abstract

Otitis media is the most common infection second only to viral upper respiratory infection in the outpatient setting. Tympanostomy tube insertion (TTI) is the most common ambulatory surgical procedure in the USA. While many risk factors for otitis media have been identified, atopic conditions have been underrecognized as risk factors for recurrent and persistent otitis media. Given that asthma and other atopic conditions are the most common chronic conditions during childhood, it is worth examining the association between atopic conditions and risk of otitis media, which can provide insight into how atopic conditions influence the risk of microbial infections. This paper focuses its discussion on otitis media; however, it is important that the association between atopic conditions and risk of otitis media be interpreted in the context of the association of atopic conditions with increased risks of various microbial infections.

Keywords

Tympanostomy tubeChildrenPediatricsOtitis mediaAdaptive immunityAllergic rhinitisAsthmaAtopic dermatitisEpidemiologyImmune dysfunctionImmune incompetenceInfectionInnate immunityPhenotypeRiskSusceptibility

Abbreviations

95 % CI

95 % confidence interval

CMI

Cell-mediated immunity

CVID

Common variable immunodeficiency

HIV

Human immunodeficiency virus

HR

Hazard ratios

ICS

Inhaled corticosteroid

IPD

Invasive pneumococcal disease

OR

Odds ratios

PAR%

Population attributable risk percent

PBMC

Peripheral blood mononuclear cells

PCV7

7-Valent pneumococcal conjugate vaccine

PPV23

23-Valent pneumococcal polysaccharide vaccine

RR

Risk ratios

Th1

T helper 1 cells

Th2

T helper 2 cells

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of Pediatric and Adolescent MedicineMayo ClinicRochesterUSA