Interleukin-31: A Novel Diagnostic Marker of Allergic Diseases

BASIC AND APPLIED SCIENCE (M FRIERI AND PJ BRYCE, SECTION EDITORS)

DOI: 10.1007/s11882-014-0423-y

Cite this article as:
Rabenhorst, A. & Hartmann, K. Curr Allergy Asthma Rep (2014) 14: 423. doi:10.1007/s11882-014-0423-y
Part of the following topical collections:
  1. Topical Collection on Basic and Applied Science

Abstract

Interleukin-31 (IL-31) is a newly discovered cytokine associated with chronic skin inflammation and pruritus. Patients with atopic dermatitis, chronic spontaneous urticaria, allergic contact dermatitis, prurigo nodularis, primary cutaneous lymphoma and mastocytosis exhibit increased serum levels of IL-31 protein and elevated IL-31 mRNA in the skin. Interestingly, in some of these diseases, IL-31 serum levels correlate with disease activity. In the present review, we particularly focus on studies investigating IL-31 as a novel diagnostic biomarker indicating the severity of allergic diseases. We highlight a recent study on IL-31 in mastocytosis, which reports on elevated serum levels of IL-31 in adults correlating with the severity of disease categories, tryptase levels and percentage of bone marrow infiltration. We conclude that growing knowledge about IL-31, its receptors and signaling pathways serves to better understand the pathogenesis of allergic diseases and may lead to the development of novel treatment approaches.

Keywords

Allergy Asthma Atopic dermatitis Cytokine Diagnosis Disease severity Interleukin-31 IL-31 IL-31 mRNA Immune response Inflammation Mast cells Mastocytosis Pruritus Skin Diagnostic marker 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of DermatologyUniversity of CologneCologneGermany

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