IMMUNE DEFICIENCY AND DYSREGULATION (DP HUSTON, SECTION EDITOR)

Current Allergy and Asthma Reports

, 14:408

First online:

Emerging Role of Human Basophil Biology in Health and Disease

  • Jessica L. CromheeckeAffiliated withDepartments of Microbial Pathogenesis & Immunology and Medicine, Texas A&M College of MedicineTexas A&M Health Science Center, Clinical Science and Translational Research Institute
  • , Kathleen T. NguyenAffiliated withDepartments of Microbial Pathogenesis & Immunology and Medicine, Texas A&M College of MedicineTexas A&M Health Science Center, Clinical Science and Translational Research Institute
  • , David P. HustonAffiliated withDepartments of Microbial Pathogenesis & Immunology and Medicine, Texas A&M College of MedicineTexas A&M Health Science Center, Clinical Science and Translational Research Institute Email author 

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Abstract

Basophils have emerged in recent years as a small but potent subpopulation of leukocytes capable of bridging innate and adaptive immunity. They can be activated through IgE-dependent and IgE-independent mechanisms to release preformed mediators and to produce Th2 cytokines. In addition to their role in protective immunity to helminths, basophils are major participants in allergic reactions as diverse as anaphylaxis and immediate hypersensitivity reactions, late-phase hypersensitivity reactions, and delayed hypersensitivity reactions. Additionally, basophils have been implicated in the pathophysiology of autoimmune diseases such as lupus nephritis and rheumatoid arthritis, and the modulation of immune responses to bacterial infections, as well as being a feature of myelogenous leukemias. Distinct signals for activation, degranulation, transendothelial migration, and immune regulation are being defined, and demonstrate the important role of basophils in promoting a Th2 microenvironment. These mechanistic insights are driving innovative approaches for diagnostic testing and therapeutic targeting of basophils.

Keywords

Basophil Allergy Anaphylaxis Autoimmunity Infection Malignancy