Current Allergy and Asthma Reports

, Volume 13, Issue 5, pp 477–486

Which Biomarkers Are Effective for Identifying Th2-Driven Inflammation in Asthma?

ASTHMA (WJ CALHOUN AND SP PETERS, SECTION EDITORS)

DOI: 10.1007/s11882-013-0376-6

Cite this article as:
Diamant, Z., Tufvesson, E. & Bjermer, L. Curr Allergy Asthma Rep (2013) 13: 477. doi:10.1007/s11882-013-0376-6

Abstract

Recognition of asthma as a heterogeneous disease revealed different potential molecular targets and urged the development of targeted, customized treatment modalities. Evidence was provided for different inflammatory subsets of asthma and more recently, further refined to T helper (Th)2-high and Th2-low subphenotypes with different responsiveness to standard and targeted pharmacotherapy. Given these differences in immunology and pathophysiology, proof of concept studies of novel treatment modalities for asthma should be performed in adequate, well-defined phenotypes. In this review, we describe both existing and novel biomarkers of Th2-inflammation in asthma that can be applied to classify asthma subphenotypes in clinical studies and for treatment monitoring.

Keywords

AsthmaPhenotypeTh2 inflammationBiomarkersEosinophilsPeriostinTARCEotaxinFenoIL-4IL-5IL-13SputumBAL

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Zuzana Diamant
    • 1
    • 2
  • Ellen Tufvesson
    • 1
  • Leif Bjermer
    • 1
  1. 1.Institute for Clinical Science, Department of Respiratory Medicine and AllergologySkane University Hospital, Lund UniversityLundSweden
  2. 2.Department of General Practice, GroningenUniversity Medical Centre GroningenGroningenThe Netherlands