Current Allergy and Asthma Reports

, Volume 13, Issue 2, pp 203–208

Role of Leukotriene Antagonists and Antihistamines in the Treatment of Allergic Rhinitis


    • Department of Otolaryngology-Head Neck SurgeryTrabzon Research and Training Hospital
  • Elina Toskala
    • Department of Otolaryngology-Head and Neck SurgeryTemple University, School of Medicine
  • Ahmet Ural
    • Department of Otolaryngology-Head Neck SurgeryKaradeniz Technical University, School of Medicine
  • Cemal Cingi
    • Department of Otolaryngology-Head Neck SurgeryEskisehir Osmangazi University, School of Medicine

DOI: 10.1007/s11882-013-0341-4

Cite this article as:
Çobanoğlu, B., Toskala, E., Ural, A. et al. Curr Allergy Asthma Rep (2013) 13: 203. doi:10.1007/s11882-013-0341-4


Allergic rhinitis is the most common atopic disorder seen in ENT clinics. It is diagnosed by history, physical exam and objective testing. Patient education, environmental control measures, pharmacotherapy, and allergen-specific immunotherapy are the cornerstones of allergic rhinitis treatment and can significantly reduce the burden of disease. Current treatment guidelines include antihistamines, intranasal corticosteroids, oral and intranasal decongestants, intranasal anticholinergics, intranasal cromolyn, and leukotriene receptor antagonists. In the mechanism of allergic rhinitis, histamine is responsible for major allergic rhinitis symptoms such as rhinorrhea, nasal itching and sneezing. Its effect on nasal congestion is less evident. In contrast, leukotrienes result in increase in nasal airway resistance and vascular permeability. Antihistamines and leukotriene receptor antagonists are commonly used in the treatment of allergic rhinitis. The published literature about combined antihistamines and leukotriene antagonists in mono- or combination therapy is reviewed and presented.


Allergic rhinitisEarly phaseLate phaseAntihistaminesMontelukastLeukotrienesLeukotriene antagonistsTreatmentHistamine

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© Springer Science+Business Media New York 2013