Current Allergy and Asthma Reports

, Volume 13, Issue 1, pp 19–26

Mucosal Immunology and Probiotics

  • Maria Luisa Dongarrà
  • Valeria Rizzello
  • Letizia Muccio
  • Walter Fries
  • Antonio Cascio
  • Irene Bonaccorsi
  • Guido Ferlazzo
BASIC AND APPLIED SCIENCE (M FRIERI, SECTION EDITOR)

DOI: 10.1007/s11882-012-0313-0

Cite this article as:
Dongarrà, M.L., Rizzello, V., Muccio, L. et al. Curr Allergy Asthma Rep (2013) 13: 19. doi:10.1007/s11882-012-0313-0

Abstract

The cross-talk between the mucosa-associated immune system and microbiota is critical in mucosal tissue homeostasis as well as in protection against infectious and inflammatory diseases occurring at mucosal sites. This recent evidence has paved the way to therapeutic approaches aimed at modulating the mucosa-associated immune system using probiotics. Different strains of probiotics possess the ability to finely regulate dendritic cell (DC) activation, polarizing the subsequent T cell activity toward Th1 (e.g. Lactobacillus (Lb) acidophilus), Th2 (Lb.reuteri and Bifidobacterium bifidum) or, as more recently demonstrated, Th17 responses induced by specific strains such as Lb.rhamnosus GG and Lac23a, the latter isolated in our laboratory. Here, we review some recent advances in our understanding of probiotics effects on mucosal immunology, particularly on cells of the innate immunity such as DCs. We also highlight our own experiences in modulating DC functions by commensal bacteria and discuss the relevance of probiotics administration in the treatment of human immunopathologies.

Keywords

ProbioticsCommensal bacteriaLABMicrobiotaLactobacilliBifidobacteriaDendritic cellsT- cell polarizationTh1Th2Th17Inflammatory bowel diseasesAllergyCrohn’s diseaseUlcerative colitisImmune-mediated diseasesInterleukinsTLRsMALTGALTIECImmunotherapyImmunopathologyAutoimmunityPRRPAMPMucosal immunology

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Maria Luisa Dongarrà
    • 1
  • Valeria Rizzello
    • 1
  • Letizia Muccio
    • 1
  • Walter Fries
    • 2
  • Antonio Cascio
    • 3
  • Irene Bonaccorsi
    • 1
  • Guido Ferlazzo
    • 1
  1. 1.Laboratory of Immunology and Biotherapy, Dept. of Human PathologyUniversity of MessinaMessinaItaly
  2. 2.ClinicalUnit for Chronic Intestinal Disorders, Dept. of Experimental and Clinical MedicineUniversity of MessinaMessinaItaly
  3. 3.Tropical and Parasitological Diseases Unit, Dept. of Human PathologyUniversity of MessinaMessinaItaly