Current Allergy and Asthma Reports

, Volume 12, Issue 5, pp 448–455

Role of Cockroach Proteases in Allergic Disease

ALLERGENS (RK BUSH, SECTION EDITOR)

DOI: 10.1007/s11882-012-0276-1

Cite this article as:
Page, K. Curr Allergy Asthma Rep (2012) 12: 448. doi:10.1007/s11882-012-0276-1

Abstract

Allergic asthma is on the rise in developed countries, and cockroach exposure is a major risk factor for the development of asthma. In recent years, a number of studies have investigated the importance of allergen-associated proteases in modulating allergic airway inflammation. Many of the studies have suggested the importance of allergen-associated proteases as having a direct role on airway epithelial cells and dendritic cells. In most cases, activation of the protease activated receptor (PAR)-2 has been implicated as a mechanism behind the potent allergenicity associated with cockroaches. In this review, we focus on recent evidence linking cockroach proteases to activation of a variety of cells important in allergic airway inflammation and the role of PAR-2 in this process. We will highlight recent data exploring the potential mechanisms involved in the biological effects of the allergen.

Keywords

CockroachAllergenProteaseDendritic cellAllergyAirway epitheliumProtease-activated receptorAirway hyperresponsivenessAllergic airway inflammationInnate immune responseNeutrophilTNF-αAlveolar macrophageEosinophilMucinCCL20GM-CSFTLRNODCD80CD86

Abbreviations

AHR

airway hyperresponsiveness

A1AT

alpha 1 antitrypsin

CE

cockroach extract

CR

cockroach

DC

dendritic cell

GC

German cockroach

mDC

myeloid dendritic cell

PAR

protease activated receptor

pDC

plasmacytoid dendritic cell

SLPI

secretory leukocyte protease inhibitor

TLR

toll like receptor

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Division of Critical Care MedicineCincinnati Children’s Hospital Medical CenterCincinnatiUSA