Sinusitis (ML Kowalski, Section Editor)

Current Allergy and Asthma Reports

, Volume 12, Issue 2, pp 144-153

Role of Medical Therapy in the Management of Nasal Polyps

  • Isam AlobidAffiliated withUnitat de Rinologia i Clínica de l’Olfacte, Servei d’Otorinolaringologia, Hospital Clínic i Universitari, IDIBAPS
  • , Joaquim MullolAffiliated withUnitat de Rinologia i Clínica de l’Olfacte, Servei d’Otorinolaringologia, Hospital Clínic i Universitari, IDIBAPS Email author 

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Abstract

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disease of the nasal and paranasal sinus mucosa that, despite differing hypotheses regarding its cause, remains poorly understood. Major symptoms are nasal congestion or blockage, loss of smell, rhinorrhea, postnasal drip, and facial pain or pressure. Among the objectives of CRSwNP management are to eradicate nasal polyps from nasal and sinusal cavities, eliminate symptoms, and prevent recurrences. Corticosteroids are the mainstay of treatment and are the most effective drugs for treating CRSwNP. Other potential treatments are nasal saline irrigation and antihistamines (in allergic conditions). Endoscopic sinus surgery is recommended when medical treatment fails. After surgery, medical treatment, including nasal and oral corticosteroids, is recommended.

Keywords

Chronic rhinosinusitis Antibiotics Antihistamines Antibiotics Anti–IL-5 Antileukotrienes Corticosteroids Macrolides Nasal decongestants Nasal douching Omalizumab Nasal polyps Medical therapy Management