Sinusitis (ML Kowalski, Section Editor)

Current Allergy and Asthma Reports

, Volume 12, Issue 2, pp 127-135

First online:

Role of Bacterial and Fungal Biofilms in Chronic Rhinosinusitis

  • Andrew ForemanAffiliated withDepartment of Otorhinolaryngology, Head, and Neck Surgery, The Queen Elizabeth Hospital
  • , Sam BoaseAffiliated withDepartment of Otorhinolaryngology, Head, and Neck Surgery, The Queen Elizabeth Hospital
  • , Alkis PsaltisAffiliated withDepartment of Otorhinolaryngology, Head, and Neck Surgery, The Queen Elizabeth Hospital
  • , Peter-John WormaldAffiliated withDepartment of Otorhinolaryngology, Head, and Neck Surgery, The Queen Elizabeth Hospital Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Chronic rhinosinusitis (CRS) is a very common condition that remains poorly understood from a pathogenic standpoint. Recent interest has been sparked by a potential role for biofilms in this process, with a significant body of evidence implicating them in inciting sinonasal inflammation. Biofilms are clearly present on the sinus mucosa of CRS patients, and their presence there is associated with severe disease characteristics and surgical recalcitrance. We are beginning to understand the importance of the species within these biofilms, but there may be other as-yet-unidentified factors at play in influencing disease outcomes. Recent exciting research has emerged documenting the immune response to the presence of biofilms—research that will ultimately solidify the nature and extent of the contribution of biofilms in CRS pathogenesis. Future research should focus on evidence-based antibiofilm treatments with reference to efficacy and timing of treatment.

Keywords

Bacterial Fungal Biofilms Chronic rhinosinusitis Microbes Sinonasal inflammation