, Volume 11, Issue 6, pp 445-446
Date: 08 Sep 2011

Spacers and Valved Holding Chambers in Asthma Drug Delivery: How Many Breaths Are Needed to Achieve Adequate Lung Deposition?

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Schultz A, Le Souëf TJ, Venter A, et al.: Aerosol inhalation from spacers and valved holding chambers requires few tidal breaths for children. Pediatrics 2010; 126(6):e1493–8.

Rating: •Of importance.

Keywords Wheezing Valved holding chambers Spacers Children Asthma Breathing Tidal breaths Inhalation Steroids Maximal breaths Maximal inhalation Tidal volume Drug delivery Maximal breath maneuver

Introduction: Wheezing disorders are more common among young children than any other group. As symptoms are primarily treated with inhaled medications, a need exists to find simple, efficient, and inexpensive methods of drug delivery. Spacers and valved holding chambers (VHCs) are devices commonly used to deliver asthma medications to young children that are simple to use and can reduce cost and side effects associated with inhalers. Previously, however, no data existed with regard to how many breaths are required to achieve adequate medication deposition in the lung.

Aims: This study was designed wit