Defects in Interleukin-17 Immunity in the Pathogenesis of Chronic Mucocutaneous Candidiasis
- David P. Huston
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Trial: Puel A, Cypowyj S, Bustamante J, et al.: Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. Science 2011, 332(6025):65–68.
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Introduction: Candida spp are commensulate fungi that can cause transient mucocutaneous symptoms of thrush, dermatitis, or vaginitis in healthy individuals but can cause persistent mucocutaneous infections or invasive and systemic disease in severely ill or immunocompromised patients . Chronic mucocutaneous candidiasis (CMC) typically begins in infancy and can be associated with staphylococcal infections. Several distinct subsets of CMC patients recently have been identified. One is patients with autoimmune regulator (AIRE) deficiency that causes autoimmune polyendocrine syndrome type 1 and is characterized by the presence of autoantibodies to interleukin (IL)-17 [2, 3]. Another is hyperimmunoglobulin E syndrome, which is associated with mutations in the transcription factor signal trans ...
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- Defects in Interleukin-17 Immunity in the Pathogenesis of Chronic Mucocutaneous Candidiasis
Current Allergy and Asthma Reports
Volume 11, Issue 5 , pp 342-344
- Cover Date
- Print ISSN
- Online ISSN
- Current Science Inc.
- Additional Links
- Chronic mucocutaneous candidiasis
- Autosomal recessive
- Autosomal dominant
- Industry Sectors
- David P. Huston (1)
- Author Affiliations
- 1. Departments of Microbial and Molecular Pathogenesis and Medicine, College of Medicine and Clinical Science and Translational Research Institute, Texas A&M Health Science Center, 2121 West Holcombe Boulevard, Suite 803, Houston, TX, 77030, USA