, Volume 11, Issue 5, pp 342-344
Date: 16 Jul 2011

Defects in Interleukin-17 Immunity in the Pathogenesis of Chronic Mucocutaneous Candidiasis

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Trial: Puel A, Cypowyj S, Bustamante J, et al.: Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. Science 2011, 332(6025):65–68.

Rating: ••Of major importance.

Introduction: Candida spp are commensulate fungi that can cause transient mucocutaneous symptoms of thrush, dermatitis, or vaginitis in healthy individuals but can cause persistent mucocutaneous infections or invasive and systemic disease in severely ill or immunocompromised patients [1]. Chronic mucocutaneous candidiasis (CMC) typically begins in infancy and can be associated with staphylococcal infections. Several distinct subsets of CMC patients recently have been identified. One is patients with autoimmune regulator (AIRE) deficiency that causes autoimmune polyendocrine syndrome type 1 and is characterized by the presence of autoantibodies to interleukin (IL)-17 [2, 3]. Another is hyperimmunoglobulin E syndrome, which is associated with mutations in the transcription factor signal trans ...