Current Allergy and Asthma Reports

, Volume 11, Issue 3, pp 230–235

The Role of IgE Production in the Pathophysiology of Rhinitis and Rhinosinusitis


DOI: 10.1007/s11882-011-0181-z

Cite this article as:
Hoddeson, E.K. & Wise, S.K. Curr Allergy Asthma Rep (2011) 11: 230. doi:10.1007/s11882-011-0181-z


A multitude of potential etiologies exist for rhinitis and rhinosinusitis. These sinonasal disorders are heterogeneous entities that are best understood by evaluating the causative factors in each individual patient. More precise diagnosis permits accurate and effective treatment. The association of allergy with sinonasal symptoms has been described for decades; however, the specific relationship between allergy, rhinitis, and rhinosinusitis is complex. Considering allergy in terms of a systemic atopic disorder, along with a local inflammatory process mediated by IgE production in sinonasal tissues, is helpful in unveiling the complex connection between allergy, rhinitis, and rhinosinusitis. This article reviews recent literature regarding local IgE and sinonasal inflammatory conditions.


RhinitisRhinosinusitisAllergyIgEImmunoglobulin ELocal productionAllergic rhinitisSuperantigenAcute rhinosinusitisAllergic fungal sinusitisChronic sinusitisChronic rhinosinusitisAllergic fungal rhinosinusitisNasal polyposis

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of OtolaryngologyEmory UniversityAtlantaUSA