Current Allergy and Asthma Reports

, Volume 11, Issue 2, pp 163–172

Gene Therapy for Allergic Airway Diseases

Authors

    • Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory MedicineGhent University Hospital
  • Kurt G. Tournoy
    • Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory MedicineGhent University Hospital
  • Guy F. Joos
    • Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory MedicineGhent University Hospital
Article

DOI: 10.1007/s11882-011-0177-8

Cite this article as:
Maes, T., Tournoy, K.G. & Joos, G.F. Curr Allergy Asthma Rep (2011) 11: 163. doi:10.1007/s11882-011-0177-8

Abstract

Airway diseases such as allergic asthma and rhinitis are characterized by a T-helper type 2 (Th2) response. Treatment of allergic airway diseases is currently limited to drugs that relieve disease symptoms and inflammation. In the search for new therapeutics, efforts have been made to treat allergic airway disease with gene therapy, and many preclinical studies have demonstrated its impressive potential. Most strategies focus on blocking the expression of proinflammatory proteins or transcription factors involved in the disease pathogenesis using antisense oligonucleotides, DNAzymes, small interfering RNA, or blocking of microRNAs using antagomirs. Changing the Th1/Th2 balance by overexpressing Th1-stimulating factors is another treatment option. Although the proof of concept is convincing in animal models, progress in humans remains limited. In this review, we focus on preclinical models to describe the recent developments and major breakthroughs for treating allergic airway diseases with gene therapy.

Keywords

Gene therapyGene transferAsthmaAllergy

Copyright information

© Springer Science+Business Media, LLC 2011