Mast cell modulation of the immune response
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Mast cells are present in nearly all vascularized tissues, but not the blood. They are best known for the prominent role they play in atopic disease. However, our current understanding of their direct and indirect roles in the immune response offers a more nuanced picture of both villain and hero. Although they are implicated in many inflammatory disorders, they also defend us from bacterial pathogens, prevent dangerous overreactions by the immune system, and even protect us from snake venom. Perhaps there is more to these maligned cells than we thought.
- Chen CC, Grimbaldeston MA, Tsai M, et al.: Identification of mast cell progenitors in adult mice. Proc Natl Acad Sci U S A 2005, 102:11408–11413. CrossRef
- Huff JJR: Biology of mast cells. In Middleton’s Allergy Principles and Practices, edn 6, vol 1. Edited by Franklin N, Adkinson JWY, Busse WW, et al. St. Louis, MO: Mosby; 2003:333–359.
- Metcalfe DD, Baram D, Mekori YA: Mast cells. Physiol Rev 1997, 77:1033–1079.
- Sayed BA, Christy A, Quirion MR, Brown MA: The master switch: the role of mast cells in autoimmunity and tolerance. Annu Rev Immunol 2008, 26:705–739. CrossRef
- Galli SJ, Nakae S, Tsai M: Mast cells in the development of adaptive immune responses. Nat Immunol 2005, 6:135–142. CrossRef
- Galli SJ, Kalesnikoff J, Grimbaldeston MA, et al.: Mast cells as “tunable” effector and immunoregulatory cells: recent advances. Annu Rev Immunol 2005, 23:749–786. CrossRef
- Malveaux FJ, Conroy MC, Adkinson NF Jr, Lichtenstein LM: IgE receptors on human basophils. Relationship to serum IgE concentration. J Clin Invest 1978, 62:176–181. CrossRef
- Ryan JJ, Kashyap M, Bailey D, et al.: Mast cell homeostasis: a fundamental aspect of allergic disease. Crit Rev Immunol 2007, 27:15–32.
- Kalesnikoff J, Galli SJ: New developments in mast cell biology. Nat Immunol 2008, 9:1215–1223. CrossRef
- Saxon A, Kepley C, Zhang K: “Accentuate the negative, eliminate the positive”: engineering allergy therapeutics to block allergic reactivity through negative signaling. J Allergy Clin Immunol 2008, 121:320–325. CrossRef
- Rivera J, Gilfillan AM: Molecular regulation of mast cell activation. J Allergy Clin Immunol 2006, 117:1214–1225; quiz 1226. CrossRef
- Kraft S, Kinet JP: New developments in FcepsilonRI regulation, function and inhibition. Nat Rev Immunol 2007, 7:365–378. CrossRef
- Gilfillan AM, Rivera J: The tyrosine kinase network regulating mast cell activation. Immunol Rev 2009, 228:149–169. CrossRef
- Yamashita Y, Charles N, Furumoto Y, et al.: Cutting edge: genetic variation influences Fc epsilonRI-induced mast cell activation and allergic responses. J Immunol 2007, 179:740–743.
- Furumoto Y, Gonzalez-Espinosa C, Gomez G, et al.: Rethinking the role of Src family protein tyrosine kinases in the allergic response: new insights on the functional coupling of the high affinity IgE receptor. Immunol Res 2004, 30:241–253. CrossRef
- Daeron M, Malbec O, Latour S, et al.: Regulation of tyrosine-containing activation motif-dependent cell signalling by Fc gamma RII. Immunol Lett 1995, 44:119–123. CrossRef
- Grimbaldeston MA, Metz M, Yu M, et al.: Effector and potential immunoregulatory roles of mast cells in IgE-associated acquired immune responses. Curr Opin Immunol 2006, 18:751–760. CrossRef
- Galli SJ, Grimbaldeston M, Tsai M: Immunomodulatory mast cells: negative, as well as positive, regulators of immunity. Nat Rev Immunol 2008, 8:478–486. CrossRef
- Mazzoni A, Siraganian RP, Leifer CA, Segal DM: Dendritic cell modulation by mast cells controls the Th1/Th2 balance in responding T cells. J Immunol 2006, 177:3577–3581.
- Gregory GD, Raju SS, Winandy S, Brown MA: Mast cell IL-4 expression is regulated by Ikaros and influences encephalitogenic Th1 responses in EAE. J Clin Invest 2006, 116:1327–1336. CrossRef
- Yao Y, Li W, Kaplan MH, Chang CH: Interleukin (IL)-4 inhibits IL-10 to promote IL-12 production by dendritic cells. J Exp Med 2005, 201:1899–1903. CrossRef
- Kambayashi T, Baranski JD, Baker RG, et al.: Indirect involvement of allergen-captured mast cells in antigen presentation. Blood 2008, 111:1489–1496. CrossRef
- Shevach EM: From vanilla to 28 flavors: multiple varieties of T regulatory cells. Immunity 2006, 25:195–201. CrossRef
- Lu LF, Lind EF, Gondek DC, et al.: Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature 2006, 442:997–1002. CrossRef
- Gri G, Piconese S, Frossi B, et al.: CD4+CD25+ regulatory T cells suppress mast cell degranulation and allergic responses through OX40-OX40L interaction. Immunity 2008, 29:771–781. CrossRef
- Kashyap M, Thornton AM, Norton SK, et al.: Cutting edge: CD4 T cell-mast cell interactions alter IgE receptor expression and signaling. J Immunol 2008, 180:2039–2043.
- Barnstein BO, Li G, Wang Z, et al.: Stat5 expression is required for IgE-mediated mast cell function. J Immunol 2006, 177:3421–3426.
- Boyce JA, Austen KF: No audible wheezing: nuggets and conundrums from mouse asthma models. J Exp Med 2005, 201:1869–1873. CrossRef
- Nakae S, Suto H, Berry GJ, Galli SJ: Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice. Blood 2007, 109:3640–3648. CrossRef
- Rozniecki JJ, Hauser SL, Stein M, et al.: Elevated mast cell tryptase in cerebrospinal fluid of multiple sclerosis patients. Ann Neurol 1995, 37:63–66. CrossRef
- Tuomisto L, Kilpelainen H, Riekkinen P: Histamine and histamine-N-methyltransferase in the CSF of patients with multiple sclerosis. Agents Actions 1983, 13:255–257. CrossRef
- Lock C, Hermans G, Pedotti R, et al.: Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat Med 2002, 8:500–508. CrossRef
- Dietsch GN, Hinrichs DJ: The role of mast cells in the elicitation of experimental allergic encephalomyelitis. J Immunol 1989, 142:1476–1481.
- Brenner T, Soffer D, Shalit M, Levi-Schaffer F: Mast cells in experimental allergic encephalomyelitis: characterization, distribution in the CNS and in vitro activation by myelin basic protein and neuropeptides. J Neurol Sci 1994, 122:210–213. CrossRef
- Levi-Schaffer F, Riesel N, Soffer D, et al.: Mast cell activity in experimental allergic encephalomyelitis. Mol Chem Neuropathol 1991, 15:173–184. CrossRef
- Secor VH, Secor WE, Gutekunst CA, Brown MA: Mast cells are essential for early onset and severe disease in a murine model of multiple sclerosis. J Exp Med 2000, 191:813–822. CrossRef
- Gregory GD, Robbie-Ryan M, Secor VH, et al.: Mast cells are required for optimal autoreactive T cell responses in a murine model of multiple sclerosis. Eur J Immunol 2005, 35:3478–3486. CrossRef
- Robbie-Ryan M, Tanzola MB, Secor VH, Brown MA: Cutting edge: both activating and inhibitory Fc receptors expressed on mast cells regulate experimental allergic encephalomyelitis disease severity. J Immunol 2003, 170:1630–1634.
- Tanzola MB, Robbie-Ryan M, Gutekunst CA, Brown MA: Mast cells exert effects outside the central nervous system to in uence experimental allergic encephalomyelitis disease course. J Immunol 2003, 171:4385–4391.
- McLachlan JB, Hart JP, Pizzo SV, et al.: Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection. Nat Immunol 2003, 4:1199–1205. CrossRef
- Sospedra M, Martin R: Immunology of multiple sclerosis. Annu Rev Immunol 2005, 23:683–747. CrossRef
- Hart PH, Grimbaldeston MA, Swift GJ, et al.: Dermal mast cells determine susceptibility to ultraviolet B-induced systemic suppression of contact hypersensitivity responses in mice. J Exp Med 1998, 187:2045–2053. CrossRef
- Byrne SN, Limon-Flores AY, Ullrich SE: Mast cell migration from the skin to the draining lymph nodes upon ultraviolet irradiation represents a key step in the induction of immune suppression. J Immunol 2008, 180:4648–4655.
- Depinay N, Hacini F, Beghdadi W, et al.: Mast cell-dependent down-regulation of antigen-specific immune responses by mosquito bites. J Immunol 2006, 176:4141–4146.
- Grimbaldeston MA, Nakae S, Kalesnikoff J, et al.: Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B. Nat Immunol 2007, 8:1095–1104. CrossRef
- Metz M, Piliponsky AM, Chen CC, et al.: Mast cells can enhance resistance to snake and honeybee venoms. Science 2006, 313:526–530. CrossRef
- Schneider LA, Schlenner SM, Feyerabend TB, et al.: Molecular mechanism of mast cell mediated innate defense against endothelin and snake venom sarafotoxin. J Exp Med 2007, 204:2629–2639. CrossRef
- Plaut M, Pierce JH, Watson CJ, et al.: Mast cell lines produce lymphokines in response to cross-linkage of Fc epsilon RI or to calcium ionophores. Nature 1989, 339:64–67. CrossRef
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