Susceptibility genes in severe asthma
- Stephen T. Holgate MD, FRCP, F Med Sci
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Asthma is a common complex disease with a very wide spectrum of severity. Although part of this may be due to differing environmental interactions and inadequate treatment, there is increasing evidence that in addition to susceptibility genes for asthma onset, there are also important genetic influences over the disease severity, response to treatment, and natural history. In this review, we bring together recent literature in the .eld of genetic influences over disease severity and discuss some of the clinical implications in terms of drug discovery and personalized medicine.
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- Susceptibility genes in severe asthma
Current Allergy and Asthma Reports
Volume 6, Issue 4 , pp 345-348
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- 1. Infection, Inflammation and Repair Division, Southampton General Hospital, MP810, F Level, South Block, SO16 6YD, Southampton, UK