Current Allergy and Asthma Reports

, Volume 5, Issue 2, pp 136–141

The role of regulatory t lymphocytes in asthma pathogenesis

  • Douglas S. Robinson
Article

DOI: 10.1007/s11882-005-0087-8

Cite this article as:
Robinson, D.S. Curr Allergy Asthma Rep (2005) 5: 136. doi:10.1007/s11882-005-0087-8

Abstract

Several subtypes of regulatory or suppressive T cells have been described that can prevent activation of effector T cells in vitro and in vivo in animal models. Recent evidence suggests a deficit in suppressive activity of both CD4+CD25+ regulatory T cells, and interleukin (IL)•10 producing regulatory T cells may play a role in development of allergic sensitization. If therapies can be devised to redress the balance between regulatory and effector T cells, there may be hope for the control and prevention of asthma.

Copyright information

© Current Science Inc 2005

Authors and Affiliations

  • Douglas S. Robinson
    • 1
  1. 1.Leukocyte Biology Section, Biomedical Sciences Division and Allergy and Clinical ImmunologyNational Heart and Lung Institute, Faculty of Medicine, Imperial College LondonLondonEngland