Current Allergy and Asthma Reports

, 5:284

Chemokine networks in atopic dermatitis: traffic signals of disease

Authors

  • Andor Pivarcsi
    • Department of DermatologyHeinrich-Heine-University
  • Bernhard Homey
    • Department of DermatologyHeinrich-Heine-University
Article

DOI: 10.1007/s11882-005-0068-y

Cite this article as:
Pivarcsi, A. & Homey, B. Curr Allergy Asthma Rep (2005) 5: 284. doi:10.1007/s11882-005-0068-y

Abstract

Atopic dermatitis is a chronic or chronically relapsing inflammatory skin disease with a prevalence ranging from 10% to 20% in children and 1% to 3% in adults of developed countries. Skin-infiltrating leukocytes play a pivotal role in the initiation and amplification of atopic skin inflammation. Recent studies demonstrated that infiltration of inflammatory cells into tissues is regulated by chemokines. A subset of chemokines including CCL27, CCL17, CCL22, CCL18, CCL11, and CCL13 are highly expressed in atopic dermatitis. The corresponding chemokine receptors are found on the main leukocyte subsets involved in allergic skin inflammation, such as T cells, eosinophils, and dendritic cells. In this article, we provide an overview of the role of chemokines in the complex immunopathogenesis of atopic dermatitis, highlighting potential areas for therapeutic intervention.

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© Current Science Inc 2005