Current Allergy and Asthma Reports

, Volume 5, Issue 1, pp 42–50

Helminth infections: Protection from atopic disorders


  • Hermelijn H. Smits
    • Department of ParasitologyLeiden University Medical Center
  • Franca C. Hartgers
    • Department of ParasitologyLeiden University Medical Center
  • Maria Yazdanbakhsh
    • Department of ParasitologyLeiden University Medical Center

DOI: 10.1007/s11882-005-0053-5

Cite this article as:
Smits, H.H., Hartgers, F.C. & Yazdanbakhsh, M. Curr Allergy Asthma Rep (2005) 5: 42. doi:10.1007/s11882-005-0053-5


Westernized countries are suffering from an epidemic rise in immunologic disorders, such as childhood allergy. A popular explanation is that the increased prevalence in allergy is due to a diminished or altered exposure to gut-dwelling microbes, resulting in a disordered immunoregulation. Various population studies have provided a strong case for the involvement of helminth infections in this respect. Detailed analysis of helminth-induced immune responses showed that helminths not only prime for polarized Th2 responses but also potently induce T-cell hyporesponsiveness. Recently, it has been demonstrated that helminths induce suppressed host immune responses by the priming for regulatory T cells. It is proposed that this regulatory T cell-inducing activity accounts for the protection observed in the development of allergic disorders. It would be interesting to define and characterize particular helminth molecules that have profound immunomodulatory capacities as a target for therapeutic application in the treatment or prophylaxis of allergic manifestations.

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© Current Science Inc 2005