Current Allergy and Asthma Reports

, Volume 5, Issue 5, pp 356–361

The role of the FOXP3 transcription factor in the immune regulation of allergic asthma

  • Carsten B. Schmidt-Weber
  • Kurt Blaser
Article

DOI: 10.1007/s11882-005-0006-z

Cite this article as:
Schmidt-Weber, C.B. & Blaser, K. Curr Allergy Asthma Rep (2005) 5: 356. doi:10.1007/s11882-005-0006-z

Abstract

Unbalanced immune reactions against allergens are caused by Th2 cells, which are the basis of immunoglobulin E (IgE)-mediated symptoms of allergy and asthma. Although Th2 cells are essential for allergy, they are not sufficient to cause disease, because regulatory T cells (Tregs) control their activity and expansion. Therefore, Tregs are assumed to play an important role not only in the sensitization but also in established allergic disease under therapy. A key factor of Tregs is FOXP3, which, upon expression, is sufficient to induce regulatory T-cell phenotypes. The initiation and suppressive function of FOXP3 and Tregs in the context of allergic asthma are discussed in this review.

Copyright information

© Current Science Inc 2005

Authors and Affiliations

  • Carsten B. Schmidt-Weber
    • 1
  • Kurt Blaser
    • 1
  1. 1.Swiss Institute of Allergy and Asthma Research (SIAF)DavosSwitzerland